KESKUSTELU

Uhkailevasta kynäniskahobitista tulikin mieleeni yksi mukava havainto liittyen käytöksen muuttumiseen D-vitamiinilisän aloittamisen jälkeen. Aikaisemmin (varsinkin talvisaikaan) saatoin olla todella äreä ja kimpaantua mitättömistä asioista. Aloitettuani D-kuurin, muutos käytöksessäni alkoi näkyä jo muutaman viikon päästä. Minusta tuli huomattavasti lempeämpi enkä enää ottanut tiettyjä asioita turhan raskaasti kuten aikaisemmin. Hetken tutkailtuani asiaa tulin siihen päätökseen, että yöunieni laadun paraneminen saattoi olla suurin tekijä luonteeni muuttumiseen. Väsyneenä kun tulee helposti mieli apeaksi ja käytös kapiseksi.

Vaikka oloni on moninkertaisesti parempi, mitä aikaisempina talvina, kärsin edelleen muutamista oireista, jotka viittaisivat kilpirauhasen vajaatoimintaan. On tehnyt mieli kokeilla suurentaa D-annostani, mutta en ole sitä vielä raaskinut tehdä ennen veren D-pit. mittauksia. Kaiken kaikkiaan tuntuu kuin kroppani kävisi vajaalla. Sydämen syke ei pääse nousemaan ja hampaat murenevat suuhun, vaikka harjaan ja huollan niitä säännöllisesti.

P.S. On muuten kumma, jos kukaan ei hOxaa millään tapaa kommentoida älykkyysosamäärääni viitaten tuohon kommenttiini kroppani vajaalla käymisestä.



Anna palaa Fränkki! Itse tykkään lukea tutkimustuloksista tältä palstalta. Lukeminen sujuu huomattavasti jouhevammin ja aina se hiirenrulla toimaa, jos ei ehdi saati halua sen paremmin tutustua joihinkin viesteihin. Yksityiskohtana voisin mainita, että nykyaikaisen kännykkäni ansiosta Cannell lähettää uutiskirjeensä minulle suoraan taskuun luettavaksi!

Mitäpä tuosta! Katsotaan saataisiinko kaffeet lentämään huomenaamuna

Ilmeisesti kuitenkin vain pieni osa D-vitamiinista on mahdollista pestä pois, kun synteesi tapahtuu Wikipedian mukaan valtaosin stratum basalessa (kuvassa punainen) ja stratum spinosumissa (kuvassa oranssi):



Vesi ei juurikaan läpäise ihon ylintä kerrosta (stratum corneumia), joten jos siitä kerroksesta on onnistunut huuhtomaan D-vitamiinia pois, tarkoittanee se että D-vitamiini on diffuntoitunut alemmista ihokerroksista ylimpään. Samalla sitä kuitenkin diffuntoituu toiseen suuntaan eli verenkiertoon. Lienee siis mahdotonta estää D-vitamiinitasojen nousua auringonoton jälkeen sillä, että hinkkaa itsensä suihkussa putipuhtaaksi, vaikka pesuveteen hieman D-vitamiinia voisikin päätyä.

Hox boxin seuraava veto lienee syyttää auringonottajia veden saastutamisesta kolekalsiferolilla ja siten hänen altistuttamisestaan liialle (riittävälle) määrelle kyseistä ainetta.

MLT

Jään myös odottamaan sitä innolla!

Samaa mietin itsekin että josko "ISO" -D-annos tsemppais kilpparia niin että voisi vähentää tai jopa lopettaa kilpparin vajislääkityksen, mutta tällä hetkellä en usko siihen.

Siis itse syön D:tä 125 mikroa ja mulla on myös Thyroxin vajislääkitys 0,1. (Molemmat annokset voisivat tosin olla isompikin kun olen liki 110 kg?)

Onko A-vitamiinillä jotain erityistä yhteisvaikutusta D:n kanssa?

"E. V. McCollum (1879–1967) erotti vuonna 1922 toisistaan A- ja D-vitamiinit, jotka esiintyivät usein yhdessä ja samoissa ravintoaineissa"
http://www.saunalahti.fi/arnoldus/a_vitam.html

Kysyn kalsidiolitason mittauksista.. lähinnä testituloksen luotettavuudesta ja mitkä tekijät saattavat vaikuttaa mittaustulokseen. MS-foorumille on silloin tällöin tullut viestejä, missä jopa 1-2 kk:n sisällä kalsidiolitasot ovat heilahdelleet todella radikaalisti. Tästä onkin herännyt ajatus että kuinka luotettava on 25ohd-mittaus? Ja myös mitkä tekijät vaikuttavat tulokseen? Esim. mikä vaikutus on juuri ennen kalsidiolimittausta otetulla reippaalla d-annostuksella, etc?

No olipa pläjäys!

Uutisissa pyörii uutinen kalsiumista ja D-vitamiinista, jossa väitetään ettei 20 µg D-vitamiiniannos itsenäisesti riittänyt estämään luunmurtumia.

Alex Vasquez ja John Cannell esittävät vastaavaa 2005 julkaistua tutkimusta vastaan murskakritiikkiä:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC558659/


Kyseisille nollatutkijoille tekisi myös gutaa lukea Mocanu et al. (2009), jossa luuntiheys parani ihan höpönä 125 µg:n annoksella vuoden kuluttua:

http://www.ajcn.org/cgi/content/abstract/89/4/1132


D-vitamiinia kehittyy Cannellin mukaan olennaisesti sebumissa eli talissa ja vesihän riittää huuhtomaan sitä pois varsin hyvin.

On myös tukea eläinkokeista viittauksena UVC-säteilyn tunnettuun kykyyn nostaa D-vitamiinitasoja, joka ei läpäise ihon ulointa kerrosta:

Some correctly say that UVC does not penetrate the outer layer of the skin very well, implying that fact would prevent vitamin D production even if UVC were effective in producing vitamin D. They fail to point out that such UV penetration of the skin is not necessary for vitamin D production. Hume, et al demonstrated that rabbits and rats respond equally well to topical vitamin D as they do to UV irradiation, both methods rapidly curing rachitic animals. That is, vitamin D is absorbed readily through the skin. Gaylor, et al found sebum contains large amounts of vitamin D's precursor, 7-dehydrocholesterol; up to 75% of 7-dehydrocholesterol in rat skin occurs in sebum. 1 2

These last two studies raise the possibility that sunbathing or using UV lights may not produce much vitamin D if you shower with soap after exposure. Water cleans the body but does not destroy as much sebum, human body oil. When you think about it, God made the perfect body oil for humans—sebum—but humans wash off her body oil and then apply body oils made by the cosmetic industry. I doubt she likes that.

En vielä osaa sanoa kuinka merkittävä ero vedellä versus saippualla peseytymisen välillä on D-vitamiinin tuotannon kannalta, mutta esimerkiksi Binkleyn tutkimuksessa surffaajilla voidaan epäillä vedenkin D-vitamiinia huuhtovaa roolia hyvästä syystä.



PS: Kokoelma Mercolan pitkiä D-vitamiinikirjoituksia, jotka ovat hyvä tapa päästä nopeasti vauhtiin D-vitamiiniin tutustumisessa:

http://swineflu.mercola.com/sites/vitam ... icles.aspx

Neonomide kirjoitti: "D-vitamiinia kehittyy Cannellin mukaan olennaisesti sebumissa eli talissa ja vesihän riittää huuhtomaan sitä pois varsin hyvin."

Onko johtopäätös huuhtoutumisesta Cannellin vai Neonomiden jäi epäselväksi. Nautittuna suositellaan rasvaliukoiselle vitamiinille öljykylpyä, mutta iholta talin joukosta sama aine liukeneekin suitsait veteen?

Asiasettiä Deestä hiusten kasvattamisklinikalta:

Vitamin D – the Re-discovered Key to Illness Prevention

By Tony Pearce RN.
Specialist Trichologist, National Trichology Services

Residing in a land of year-round sunshine & outdoor lifestyle, it may come as a revelation that many people here in Australia are Vitamin D (25(OH) D) deficient. Vitamin D (as Cholecalciferol) is synthesized from sunlight when our bare skin is exposed. In a further conversion cascade involving enzymes from the liver & kidneys, the active & most potent form of Vitamin D – termed Calcitriol – is produced & stored in the liver & to a lesser extent, the tissues of the body.

Although commonly referred to as a ‘vitamin’, Calcitriol is a biological response-modifying steroid hormone – and now understood to be one of the most influential steroid hormones in the body. 25(OH) D has emerged as the 2nd most important nutrient (after iron) in healthy body functioning.

Vitamin D is essential for the active absorption of Calcium & Phosphorus from the gut. It then regulates their utilisation within the body. Vitamin D is integral to the production & balance of cells that constantly remodel our bones – these cells are known as osteoclasts & osteoblasts. Vitamin D also helps prevent Calcium and some other minerals from being excreted via the kidneys.

Vitamin D deficiency is known to be associated in osteoporosis, impaired immunity, diabetes, high blood pressure, ‘stroke’, heart disease, liver disease, depression + other disturbance of mood, body muscle mass wasting, gum disease, & certain forms of cancer.

Sutherland et al (1992) postulates Vitamin D deficiency is linked to the neuro-degeneration of Alzheimer’s disease. Two recent studies found cognition and mental clarity of dementia patients improved when 25(OH) D levels were optimized (200nmol/L): (Oudshoorn C, et al. 2008) + (Llewellyn DJ, et al 2009).

The potential to develop autoimmune conditions such as alopecia areata, vitiligo, psoriasis, & inflammatory bowel disease is believed to increase with Vitamin D deficiency. Asthma exacerbation in children may be increased by 70% when the child is 25(OH) D deficient: Low vitamin D linked to asthma exacerbations.

Autoimmune Thyroiditis patients can reduce or eliminate thyroid antibodies by maintaining Vitamin D levels of at least 125nmol/L (as will a Gluten-free diet).

Collectively known as a T-Helper 1 cytokine-mediated inflammatory disorder - the symptoms & prognosis of these diseases may be significantly improved with Vitamin D supplementation (up to 12,500 IU per day). Physiological doses of Vitamin D alter gene response, and appear to suppress Macrophage (white blood cell) pro-inflammatory cytokine response.

Multiple Sclerosis (MS) is a degenerative disorder of the Central Nervous System where ‘demyelination’ of nerve fibres within the brain + spinal cord occurs. Epidemiological studies increasingly indicate a correlation between 25(OH) D levels and the course of the disease. An open study by Kimball et al (2007) found direct evidence that Vitamin D supplementation (up to 10,000IU/day) helps treat MS. Incredibly – the number of neurological lesions per patient in the treatment group decreased; and they experienced fewer summer exacerbations of their MS. Ward, KA, et al: (2009) found Vitamin D is highly associated with neuromuscular performance in athletic competition.

An 8 year study of over 34,000 women found there is an 11% reduction for risk of breast cancer when women have ‘normal’ levels of 25(OH) D compared to subjects with low or deficient levels (Robien, K., Cutler, GJ, Lazovich, D: September, 2007).

There are now many studies (http://www.vitamindcouncil.org) which demonstrate that an optimal Vitamin D status during pregnancy is essential for both maternal well-being and in-utero development of the child. There is also a growing awareness of the link between gestational Vitamin D deficiency in the pregnant mother and autism in her still-unborn child: Canadian Paediatric Society. Vitamin D supplementation: Recommendations for Canadian mothers and infants. Paediatr Child Health 2007;12(7):583-9 + Cannell JJ. Autism and Vitamin D. Med Hypotheses 2008;70(4):750-9.

An earlier paper by Cannell et al (2006) proposed a convincing correlation between Vitamin D supplementation & an increased resistance to seasonal epidemic influenza.

The mortality rate of 25(OH) D replete males with biopsy-confirmed prostate cancer is decreased by up to SIX times over 25(OH) D deficient males with same stage prostate cancer (Tretli, S. et al: 2009).

‘Statin’ drugs deplete the body of Co-enzyme Q10; causing debilitating myositis and myalgia in some patients. 25(OH) D supplementation to levels >125nmol/L reversed these conditions in 92% of patients (Ahmed, W. et al: 2009)

If we totally avoid the sun, our bodies require around 4,000 International Units (IU) i.e. 100 micrograms of Vitamin D per day. Approximately 20-30 minutes of strong sunlight on bare, non-sun screened skin will produce approximately 20,000 IU of 25(H) D – providing a ready reserve of stores. Once these levels are achieved, the skin combines with ultra-violet light to limit Vitamin D production; corrupting excess Cholecalciferol so it cannot be further converted. According to Vieth (1999) there has never been a substantiated case of Vitamin D toxicity from sun exposure alone.

Common Reasons for Poor 25(OH) D Absorption + Deficiency:

* Genetic tendency to be low in Vitamin D or the body may synthesise/convert it more slowly.
* Gut/Biliary dysfunction resulting in fat malabsorption (termed Steatorrea)
* Oral 25(OH) D supplements are best absorbed in the presence of a fatty-acid protein meal, and so are generally poorly absorbed by practicing Vegans or Vegetarians. These individuals require regular sun exposure or Vitamin D injections to prevent deficiency.
* Darker skinned people such as full-blood Aborigines, Pacific Islanders,
* Sub-Continent* or African immigrants need five to ten times longer exposure to synthesise the same amounts of Vitamin D that a fair skinned person would produce in 20-30 minutes. Because of this, dark-skinned folk are at greater risk of Vitamin D deficiency when removed from their traditional environment.
* Disorders of the liver may impair Cholecalciferol conversion (termed hydroxylation). Patients with non-alcoholic fatty liver disease often have marked 25 (OH) D deficiencies (Targher, G. et al: 2007).
* Medication-induced deficiency: taking Phenytoin Sodium (Dilantin) in long-term anti-convulsant therapy.
* Air pollution in large urban cities reduces solar UVB wavelengths of light from which Vitamin D is synthesised.
* Bathing/showering too soon after sunlight exposure can wash away the 25(OH) D being produced ON the skin’s surface (Holick, MF et al: 1980). In their rat skin studies, Gaylor et al (1964) found sebum – natural skin oil produced by sebaceous glands - retained > 70%.of 25(OH) D’s precursor: 7-dehydrocholesterol.

Dietary sources of Vitamin D are egg yolk; ‘oily’ fish such as salmon & sardines, cod liver oil**, Vitamin D fortified bread & cereals, or milk. Be mindful though a standard glass of milk will provide about 100 IU of Vitamin D only, so in Australia sensible sunlight exposure and/or supplementation in the colder months is the most effective means to maintain optimal Vitamin D levels.

The nutritional co-factors essential to activate 25(OH) D are Magnesium, Potassium, Zinc and the trace element Boron. All of these nutrients can be found in fresh spinach.

Assessing Vitamin D levels is achieved via blood pathology for 25-OH Vitamin D. New reference ranges (NEJM 357:3 July19th 2007) are 50-200 nmol/L. Levels less than 75nmol/L is considered Vitamin D insufficiency, whilst levels less than 50nmol/L is deemed ‘deficient’.

Vitamin D, Oestradiol (E2) and Thyroid hormone belong to a class of steroid hormones termed ‘C-ERB’. As such they are structurally similar, closely related and posses the capacity to influence the other’s expression:

* Triiodothyronine (T3) thyroid hormone receptor expression is enhanced when 25 (OH) D is sustained above 100nmol/L (Lee: 2007).
* Vitamin D is Thyroid + Cortisol hormone ‘sparing’ when 25(OH) D levels are maintained at 150-200nmol/l. Our bodies operate more efficiently with less demand for Thyroid + Cortisol hormone.

If we totally avoid sunlight exposure our bodies require an average 4,000IU Vitamin D per day, so a minimum supplementation of 5,000IU per day is recommended by the Vitamin D Council to maintain stores and avoid deficiency. Integrative Medical Practitioners may prescribe up to 12,500IU to patients with severe or intractable deficiency.

Vitamin D can be toxic when large amounts (i.e. >50,000 IU) is supplemented for prolonged periods of time.

Vitamin D supplementation should be prescribed by an experienced Health Practitioner after Vitamin D blood levels are established. Vitamin D3 – known as Cholecalciferol - is the only form of Vitamin D supplement that should be taken, as it’s the one naturally-occurring form for our bodies. All other forms of Vitamin D are metabolic or chemical alterations. Ergocalciferol is plant-derived Vitamin D2 – and is approximately 100 times LESS efficacious than Vitamin D3 (Lee: 2007).

Finally – in the current climate of H1N1 (Swine Flu) hysteria – an interesting ‘side effect’ of Vitamin D: those of us with replete 25(OH) D levels would be very unlikely to generate an immune response from ‘Flu vaccine inoculation. Two Russian studies found hi-range Vitamin D levels de-activate immune response which the vaccine is attempting to generate (Shadrin, AS. et al: 1977 + Zykov, MP, Sosunov, AV: 1987). It’s as if the body is saying ‘with high Vitamin D levels I don’t need this.’

This article is dedicated to Dr. JJ Cannell MD, Director of the Vitamin D Council. His tireless crusade to re-establish the importance of Vitamin D in long-term health is yet to be fully appreciated by some areas of orthodox medicine + public health regulators.

*Goswami, R. et al (2009) found the average 25 (OH) D levels among Indian people was only 17.5nmol/L!! This is severe Vitamin D deficiency.

**Supplementing Cod Liver Oil to correct Vitamin D deficiency is NOT desirable because of the high Vitamin A content found in Cod Liver Oil.

http://www.hairlossclinic.com.au/articl ... iency.html

Olipas sikamaisen hyvä pläjäys random-artikkeliksi mikä sattui vaan eteen. Läskiytin joitain erityisen asiallisia uusia ja vanhoja tutkimuksia.

Lamberg-Allardtin väitteet että vain D-vitamiinin luustovaikutuksista on hyvää näyttöä ovat hyvin outoja ja jonkun pitäisi kertoa se hänelle suoraan.

No niin, nyt on lukumaratonien aika, GrassrootHealthissa koko läjä 2009 pidetyn syöpäseminaarin slaideja ihailtavaksi:

Symposium in Print 2009
Epidemiology of Vitamin D & Cancer

[PDF] Symposium in Print on the Epidemiology of Vitamin D and Cancer
Cedric F. Garland
http://www.grassrootshealth.net/media/d ... r_2009.pdf

[PDF] Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D
Reinhold Vieth
http://www.grassrootshealth.net/media/d ... p_2009.pdf

[PDF] Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000
William B. Grant, Sharif B. Mohr
http://www.grassrootshealth.net/media/d ... r_2009.pdf

[PDF] Vitamin D and Melanoma
Kathleen M. Egan
http://www.grassrootshealth.net/media/d ... a_2009.pdf

[PDF] Vitamin D and Breast Cancer
Elizabeth R. Bertone-Johnson
http://www.grassrootshealth.net/media/d ... r_2009.pdf

[PDF] Vitamin D for Cancer Prevention: Global Perspective
Cedric F. Garland, Edward D. Gorham, Sharif B. Mohr, Frank C. Garland
http://www.grassrootshealth.net/media/d ... t_2009.pdf

[PDF] Vitamin D Status: Measurement, Interpretation, and Clinical Application
Michael F. Holick
http://www.grassrootshealth.net/media/d ... s_2009.pdf

[PDF] A Brief History of Vitamin D and Cancer Prevention
Sharif B. Mohr
http://www.grassrootshealth.net/media/d ... r_2009.pdf

[PDF] Vitamin D and Cancer Incidence in the Harvard Cohorts
Edward Giovannucci
http://www.grassrootshealth.net/media/d ... d_2009.pdf

[PDF] Vitamin D and Pancreatic Cancer
Rachael Z. Stolzenberg-Solomon
http://www.grassrootshealth.net/media/d ... r_2009.pdf

[PDF] Vitamin D and Intervention Trials in Prostate Cancer: From Theory to Therapy
Gary G. Schwartz
http://www.grassrootshealth.net/media/d ... r_2009.pdf

http://www.grassrootshealth.net/symposium-in-print

Toinen seminaari viime marraskuulta kaupan päälle !

Diagnosis and Treatment of Vitamin D Deficiency Seminar

November 3, 2009

[PDF] Introduction to Vitamin D
by Reinhold Vieth Ph.D.
http://www.grassrootshealth.net/media/d ... _intro.pdf

[PDF] What's a Vitamin D Deficiency?
by Robert P. Heaney, M.D.
http://www.grassrootshealth.net/media/d ... heaney.pdf

[PDF] Viewing Breast Cancer as a Deficiency Disease
by Cedric F. Garland, Dr.P.H.
http://www.grassrootshealth.net/media/d ... arland.pdf

[PDF] Vitamin D in the Breast Clinic
by Tracey L. O’Connor, M.D.
http://www.grassrootshealth.net/media/d ... connor.pdf

[PDF] Sources of Vitamin D
by Susan J. Whiting
http://www.grassrootshealth.net/media/d ... hiting.pdf

[PDF] Vitamin D and Control of Infectious Diseases
by John H. White
http://www.grassrootshealth.net/media/d ... 3white.pdf

[PDF] Solving Vitamin D Deficiency –A Safety Profile - Identify and Quantify Risk Levels of Vitamin D
by Reinhold Vieth Ph.D.
http://www.grassrootshealth.net/media/d ... 3veith.pdf

http://www.grassrootshealth.net/seminar-nov2009

Carole Baggerlyn näppärä ½ tunnin video Deestä, kiteyttää paljon:

http://www.youtube.com/watch?v=TQ-qekFo ... r_embedded

Kyseinen ihminen on maksettu hiljaiseksi.

Niinhän täällä on tapana tehdä.

Muuten ei mene lääkkeet kaupaksi.