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jussipussi
Seuraa 
Viestejä52103

Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Yleensä kun kirjoittaja littää hymiöitä niin aihe on aikalailla taputeltu.

jussipussi
Seuraa 
Viestejä52103

"Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study

Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25(OH)D], total testosterone (TT), and free testosterone (FT) in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7 ± 7.9 years, and the mean serum 25(OH)D, TT and FT levels were 21.23 ± 7.9 ng ml−1 , 4.70 ± 1.6 ng ml−1 , and 8.12 ± 3.3 pg ml−1 , respectively. In the multiple linear regression model, 25(OH)D showed positive association with TT (β =0.137, P< 0.001) and FT (β =0.103, P= 0.008). 25(OH)D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25(OH)D < 20 ng ml−1 ] was associated with an increased risk of deficiencies of TT (<2.30 ng ml−1 ) (odds ratio [OR]: 2.65; 95% confidence interval [CI]: 1.21-5.78, P= 0.014) and FT (<6.50 pg ml−1 ) (OR: 1.44; 95% CI: 1.01-2.06 P= 0.048) after adjusting for age, season, body mass index, body composition, chronic disease, smoking, and alcohol use.

In conclusion, we demonstrated a positive correlation between 25(OH)D and testosterone, which showed similar seasonal variation in Korean men."

http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=1... .

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Käyttäjä4499
Seuraa 
Viestejä7100

jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Haluaisitko jotain "jumala on totuus ja tie" tyyppistä kirjoitettavan tuon sijasta? 

Mutta siinähän on jo. Juuri se oli asiassa hauskaa. Plausible = USKOttava...

Mut ei siinä mitään. Tiedon karttuessa, D-vitamiiniin suhtautumisessa on ollut yhä enemmän uskonnollisiakin piirteitä. Huolestuttavaa on vain se, jos uskon asiat ei meinaa enää kunnolla erottua todistetuista asioista.

Hypoteesit on ok!

Käyttäjä4499
Seuraa 
Viestejä7100

jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Yleensä kun kirjoittaja littää hymiöitä niin aihe on aikalailla taputeltu.

Niin sitä äkkiseltään luulisi, mutta asian laita on päinvastoin. Nimenomaan päinvastoin.

jussipussi
Seuraa 
Viestejä52103

"The VITamin D and OmegA-3 Trial (VITAL) is the largest and most recent to test whether vitamin D or fish oil can effectively prevent cancer or cardiovascular disease. Results to date have been mixed but show promise for some outcomes, now confirmed by updated pooled (meta) analyses. The latest results from VITAL will be presented during The North American Menopause Society (NAMS) Annual Meeting in Chicago, September 25-28, 2019.

Nearly 26,000 U.S. men and women participated in the nationwide VITAL clinical trial. After more than five years of study and treatment, the results show promising signals for certain outcomes. For example, while Omega-3 fatty acids (fish oil) showed only a small, but nonsignificant, reduction in the primary cardiovascular endpoint of major CVD events, they were associated with significant reductions in heart attacks. The greatest treatment benefit was seen in people with dietary fish intake below the cohort median of 1.5 servings per week but not in those whose intake was above that level. In addition, African-Americans appeared to experience the greatest risk reductions. The heart health benefits are now confirmed by recent meta-analyses of omega-3 randomized trials.

Similarly, vitamin D supplementation did not reduce major CVD events or total cancer incidence but was associated with a statistically significant reduction in total cancer mortality among those in the trial at least two years. The effect of vitamin D in reducing cancer death is also confirmed by updated meta-analyses of vitamin D trials to date.

"The pattern of findings suggests a complex balance of benefits and risks for each intervention and points to the need for additional research to determine which individuals may be most likely to derive a net benefit from these supplements," says Dr. JoAnn Manson, lead author of the study from Brigham and Women's Hospital, an affiliate of Harvard Medical School.

"With heart disease and cancer representing the most significant health threats to women, it is imperative that we continue to study the viability of options that prevent these diseases and help women survive them," says Dr. Stephanie Faubion, NAMS medical director."

https://medicalxpress.com/news/2019-09-vitamin-d-fish-oil-cancer.html .

jussipussi
Seuraa 
Viestejä52103

Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Haluaisitko jotain "jumala on totuus ja tie" tyyppistä kirjoitettavan tuon sijasta? 

Mutta siinähän on jo. Juuri se oli asiassa hauskaa. Plausible = USKOttava...

Mut ei siinä mitään. Tiedon karttuessa, D-vitamiiniin suhtautumisessa on ollut yhä enemmän uskonnollisiakin piirteitä. Huolestuttavaa on vain se, jos uskon asiat ei meinaa enää kunnolla erottua todistetuista asioista.

Hypoteesit on ok!

Tiedon karttuessa oletusten osuus vähenee  joten väitteesi on väärä.

jussipussi
Seuraa 
Viestejä52103

Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Haluaisitko jotain "jumala on totuus ja tie" tyyppistä kirjoitettavan tuon sijasta? 

Mutta siinähän on jo. Juuri se oli asiassa hauskaa. Plausible = USKOttava...

Ei  se ole hauskaa vaan oleellista ymmärtää.

“To be useful, your beliefs should be constrained by the logic of probability.”
― Daniel Kahneman, Thinking, Fast and Slow

Googlen käännös.

"Jotta uskomuksesi olisi hyödyllistä, sitä tulee rajoittaa todennäköisyyden logiikalla."

https://www.goodreads.com/author/quotes/72401.Daniel_Kahneman?page=2 .

Jos haluat 100% uskon varmuutta aukaise vaikka raamattu. Tieteessä sitä ei tule koskaan olemaan.

"What is meant by no amount of experiment can ever prove me right, a single experiment can prove me wrong?

All observations and conclusions in physics are probabilistic in nature. When we carry out an experiment to measure a quantity in physics, say “g”; we get an answer. We accept our answer within a certain degree of accuracy. We repeat the experiment a 100 different times, at 100 different locations, under identical conditions, and we obtain the same answer within the same degree of certainty, let’s say + or - 3%. But all these results that are in agreement, do not qualify (validate) our hypothesis to be absolutely and categorically true. The probabilistic nature of physical principles tells us that there is no guarantee that the next time we repeat the experiment, we will get a result within the same degree of uncertainty. In fact, we may not even come close. There is even a chance that we may be off by 100%! This means two things: a) even if we repeat the experiment an infinite times getting the same answer each time, probability tells us that when we repeat it the n = infinity + 1 time, we may get a different answer! b) if, during a single trial, we obtain an appreciably different answer without identifying errors in our steps (especially if there are no errors) then that one experiment would be enough to invalidate our hypothesis! Repeating a trial that was a failure and getting an acceptable answer DOES NOT erase the huge uncertainty that the one failure developed!"

https://www.quora.com/What-is-meant-by-no-amount-of-experiment-can-ever-... .

jussipussi
Seuraa 
Viestejä52103

Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Yleensä kun kirjoittaja littää hymiöitä niin aihe on aikalailla taputeltu.

Niin sitä äkkiseltään luulisi, mutta asian laita on päinvastoin. Nimenomaan päinvastoin.

Hymiö vihjaa siitä että argumentoijalla tunne voittaa järjen.

jussipussi
Seuraa 
Viestejä52103

"New study reveals a strong link between vitamin D deficiency and increased mortality, especially diabetes-related deaths

...The researchers took their data from the records of all 78,581 patients (mean age 51.0 years, 31.5% male) who had a vitamin D (25D) measurement taken at the Department of Laboratory Medicine, General Hospital of Vienna between 1991 and 2011, which was then matched with the Austrian national register of deaths. The first 3 years of mortality following the vitamin D measurement were excluded from the analysis, and patients were followed for up to 20 years where possible, with a median follow-up of 10.5 years.

The authors used a blood level of vitamin D 50 nmol/L, a commonly used cut-off value for vitamin D deficiency, as their reference value to which other levels would be compared, and set their low and high levels for which risk would be calculated at 10 nmol/L and 90 nmol/L respectively.

The study found that vitamin D levels of 10 nmol/L or less were associated with a 2-3 fold increase in risk of death, with the largest effect being observed in patients aged 45 to 60 years (2.9 times increased risk). Levels of 90 nmol/L or greater were associated with a reduction in all-cause mortality of 30-40%, again with the largest effect being found in the 45 to 60-years-old age group (a 40% reduction in risk). No statistically significant associations between vitamin D levels and mortality were observed in patients over the age of 75

With regard to cause-specific mortality, the authors were surprised to find the strongest associations of vitamin D were with causes of death other than cardiovascular disease and cancer.

Differences between the age groups were even more pronounced for these causes of death and, again, the largest effect was found in patients aged 45 to 60 years. Further subdivision of these non-cardiovascular, non-cancer causes of death revealed the largest effect of vitamin for diabetes with a 4.4 times higher risk of death from the disease in the vitamin D deficient group (less than or equal to 50 nmol/L) than for study participants whose serum vitamin D was above 50 nmol/L.

Plotting the risk of death according to vitamin D level in the various subgroups did not support a risk resurgence at higher vitamin D levels above 100 nmol/L. The authors say this further diminishes concerns about a possible negative effect of vitamin D in the higher concentration range, as have been shown in some previous studies reporting "inverse J-shaped" risk association (meaning risk decreased to a certain level of vitamin D and then started increasing again at higher levels).

The team conclude: "Our survival data from a large cohort, covering all age groups, from a population with minimal vitamin D supplementation at old age, confirm a strong association of vitamin D deficiency (under 50 nmol/L) with increased mortality. This association is most pronounced in the younger and middle-aged groups and for causes of deaths other than cancer and cardiovascular disease, especially diabetes."

The researchers go on to suggest that: "Our findings strengthen the rationale for widespread vitamin D supplementation to prevent premature mortality, emphasize the need for it early in life and mitigate concerns about a possible negative effect at higher levels."

https://medicalxpress.com/news/2019-09-reveals-strong-link-vitamin-d.html .

Käyttäjä4499
Seuraa 
Viestejä7100

jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Haluaisitko jotain "jumala on totuus ja tie" tyyppistä kirjoitettavan tuon sijasta? 

Mutta siinähän on jo. Juuri se oli asiassa hauskaa. Plausible = USKOttava...

Mut ei siinä mitään. Tiedon karttuessa, D-vitamiiniin suhtautumisessa on ollut yhä enemmän uskonnollisiakin piirteitä. Huolestuttavaa on vain se, jos uskon asiat ei meinaa enää kunnolla erottua todistetuista asioista.

Hypoteesit on ok!

Tiedon karttuessa oletusten osuus vähenee  joten väitteesi on väärä.

D-vitamiinin kohdalla näyttäisi monesti tapahtuvan päinvastoin... joten toteamukseni on sitäkin oikeampi.

Käyttäjä4499
Seuraa 
Viestejä7100

jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
Käyttäjä4499 kirjoitti:
jussipussi kirjoitti:
"Causal Link Between Vitamin D and Total Testosterone in Men

A Mendelian Randomization Analysis

Main Outcome Measure: Total T was detected by chemiluminescence assay.

Results: Lower 25(OH)D levels were associated with lower total T (β, 0.40; 95% CI, 0.23 to 0.58) after multivariable adjustment. Per-SD increase in the vitamin D GRS (VD_GRS) was significantly associated with 25(OH)D (β, −1.64; 95% CI, −2.04 to −1.24) and with total T (β, −0.19; 95% CI, −0.37 to −0.02). Using VD_GRS as the instrumental variable in the MR analysis, the causal regression coefficient of genetically determined per-SD increase for 25(OH)D on total T was 0.12 (95% CI, 0.02 to 0.22).

Conclusion: We provide evidence for the biologically plausible causal effects of 25(OH)D on total T using MR analysis. Whether vitamin D supplementation can raise androgen levels merits further investigation in long-term, randomized controlled trials."

https://www.medscape.com/viewarticle/916868 .

PLAUSIBLE... 😂

Haluaisitko jotain "jumala on totuus ja tie" tyyppistä kirjoitettavan tuon sijasta? 

Mutta siinähän on jo. Juuri se oli asiassa hauskaa. Plausible = USKOttava...

Ei  se ole hauskaa vaan oleellista ymmärtää

Olin juuri vastaamassa tähän, kun sain kutsun naapuripöytään maistamaan tänään suolattua tonnikalaa! Tuli vähän juotua paikallista tsippuroa vai mitä onkaan... Mm. Mihin jäinkään. Oleellisen hauskaa...

jussipussi kirjoitti:
"Jotta uskomuksesi olisi hyödyllistä, sitä tulee rajoittaa todennäköisyyden logiikalla."

Ei uskomus sillä hyödylliseksi muutu, että sitä rajoittaa: hyödyllisyys lähtee itse uskomuksesta. Ts. ei ole syytä edes muodostaa mielikuvituksesta uskomuksia enemmän kuin logiikka sallii.

jussipussi kirjoitti:
Jos haluat 100% uskon varmuutta aukaise vaikka raamattu. Tieteessä sitä ei tule koskaan olemaan.

Ihan turha syöttää mulle pajunköyttä vedoten siihen, että tieteessä usko on etuoikeutettua: usko on uskoa, oli se sitten julkaistu lehdessä tai raamatussa. Kuinka oikeutettua on uskoa, ja perusteltua että muidenkin olisi syytä uskoa, se on toinen asia.

(Mitä edes tarkoittaa "100% uskon varmuutta" - eikö se ole paradoksaalista? Varmuutta joo, uskoa joo, mutta "uskon varmuutta"?)

Kyse on nyt siitä, myönnetäänkö usko vai ei. Esitetäänkö hypoteesi, vai riennetäänkö vetämään totuuksia hatusta, vedoten todennököisyyteen?

Todennäköisyydessä on aina uskon piirre... ja se on monesti kyllin hyvää totuudeksi - mutta ei sitä uskon osuutta voi kuroa umpeenvain sillä perusteella, että "raamatussakin tehdään niin".

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