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Yeni Mihova
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Viestejä3780

Omituinen ilmaisu tuo "ruiskutti virusta", sillä kyseessä on vain adenoviruksesta tehty vektori ilman mitään viruksen omaa perimää seassa. Tuo vektori vie kohteeseen kolmea neljstä Yamanaka-factorista, jotka ovat Oct4 (also known as Pou5f1), Sox2 and Klf4 geenit(, eli OSK). Sinclairin ryhmä ei tarvitse sitä neljättä, e-Myc:iä, joka on muutenkin syöpäherkkä veijari.

Noilla Yamanaka-faktoreilla palautetaan nuori metylaatiokuvio.

Hieno osoitus, missä nuorennustekniikka nykyään menee.

Ja hieno osoitus vahvistus sille, että hieman mietityttää hankkia immuniteetti adenokuljettimelle esimerkiksi koronarokotteen myötä.

I want a perfect body
I want a perfect soul

Yeni Mihova
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Viestejä3780

Jotta viisarin veivaaminen ei mene liian nuoreksi asti, käyttää Sinclairin ryhmä tiettyä antibioottina on/off-katkaisimena. Liian nuoreksi puskettu ei tietenkään toimi.

I want a perfect body
I want a perfect soul

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Yeni Mihova
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Viestejä3780

Paljon tämän lehden versiota parempi katsaus tuohon tutkimukseen ja sen tekniikkaan löytyi The Scientistista:

https://www.the-scientist.com/news-opinion/genetic-reprogramming-restore...

Harvard Medical School geneticist David Sinclair and his colleagues aimed to reset the biological clocks of a group of cells to see if they could rejuvenate injured and aging cells. They looked to genes that encode transcription factors that de-differentiate cells. These so-called Yamanaka factors, named after biologist Shinya Yamanaka, are widely used to generate induced pluripotent stem cells (iPSCs). In a 2016 Cell paper, a different group of scientists had activated these transcription factors in mice with progeria, a condition that causes premature aging, and found that the treatment alleviated symptoms and extended their lifespan by a matter of weeks. These findings raised the possibility that Yamanaka factors could hold the key to counteract aging.
A risk of using Yamanaka factors in vivo is that dedifferentiation can cause cells to divide rapidly, so researchers in the Cell study only turned them on in short bursts. To avoid such out-of-control proliferation, which would risk causing cancerous growth, Sinclair’s team eliminated one of the Yamanaka factors from their study—MYC, which is a known oncogene—and fitted the remaining three into an adeno-associated virus and injected it into mice. The researchers found that the mice didn’t develop tumors, even after more than a year. The next challenge: to see if these transcription factors could successfully revert old and injured neurons back to a more youthful and healthy state. The eyes were a logical target because younger mice can regrow axons of ocular neurons, unlike older mice.

The team focused on retinal ganglion cells (RGCs), which are neurons whose axons make up the optic nerve and snake their way into the brain, transmitting information from light-sensitive photoreceptors. Although these cells can regenerate if injured during development, they typically lose their ability to heal within a few days of a mouse’s birth. To test whether adult mice can regain this ability, the researchers crushed the optic nerves of some mice and induced glaucoma in another set of mice by inserting tiny beads into their eyes, then injected the virus encoding the three transcription factors into all the mice’s eyes.

The treatment caused mice to grow new axons from RGCs that reached back into the brain and halted glaucoma progression. The rodents with glaucoma regained around half of their lost visual acuity, marking the first time that mice with a glaucoma-like condition have restored vision loss.

“Vision loss from glaucoma was not thought to be recoverable,” says Sinclair. “Bruce [Ksander, a collaborator] called me at ten o’clock at night and told me the news. It was difficult to believe.”

I want a perfect body
I want a perfect soul

Homer_Backland
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Viestejä14230

Totta...aletaan olla silloin jo Einsteinin mystisessä 12 -ulotteisessa avaruudessa jossa aika eikä massa eikä mikään enään toimi.

“Before you diagnose yourself with depression or low self-esteem, first make sure that you are not, in fact, just surrounded by assholes.”
— William Gibson

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