Testosteronia kutsutaan usein "mieshormoniksi", vaikka sillä on välttämättömän tärkeitä tehtäviä myös naisen kehossa mm. ihon laadun, lihaskunnon ja libidon sekä mielialan määrän ja laadun ylläpitämiseksi. Aivan kuten "naishormoneilla" estrogeenillä ja progesteronilla on välttämättömiä tehtäviä miehen kehossa.
Pitäisikö testosteronia tutkia/antaa useammin myös naisille?
While the role of testosterone in maintaining muscle mass and losing body fat may be obvious to bodybuilders and athletes, it is a basic hormonal fact that is often absent in the medical community. It is known that many women begin to gain fat rapidly about ten to fifteen years before the menopause and also after. The connection between low to absent testosterone production and the deterioration of a healthy body composition is rarely made. Most women are often only given estrogens and progestins as hormone replacement therapy, but not testosterone. I have found in my medical practice that giving women estrogen and progesterone and not testosterone makes it almost impossible for them to lose weight/fat.
So why isn’t testosterone more commonly given for weight loss in women? The medical community actually commonly believes testosterone causes obesity. This is due to a number of studies linking upper body obesity /abdominal obesity in women to elevated testosterone levels. Once again, this is a case of blaming one hormone as a "villain". In these women, they do in fact have higher than normal testosterone levels but their whole hormonal system is out of balance. Not only do they have high testosterone levels, but they also have poor insulin sensitivity as well as high insulin levels. Often these women have a metabolic problem of insulin resistance—which is associated with obesity. There is no serious evidence that testosterone replacement therapy for women will result in greater body fat – in fact the opposite is true.
A recent controlled study showed that oral estrogens caused a gain in fat mass and loss in muscle, with a decrease in IGF-1 levels (O'Sullivan et al, 1998)
With the social stigma against testosterone and anabolic steroids in general, and it is difficult enough to get a study approved on testosterone in men. Imagine how difficult it is to get a human use committee to approve a study on testosterone in women! However, there is one study that helped to illuminate the potential for androgens to help women lose fat. Lovejoy et al, in 1996, compared the effects of nandrolone decanoate and the anti-androgen drug spironolactone on body composition in obese, postmenopausal women. The dose given the nandrolone group was low – 30 mg every other week. All women in the study were put on a calorie restricted diet (500 calories below lean mass maintenance), and were told not to change their exercise habits. After nine months, the women receiving nandrolone lost an average of 3.6 percent of their bodyfat while the placebo group lost only 1.8 percent and the spirolactone (an anti-androgen) only .5 percent. Nandrolone doubled the rate of fat loss over the placebo and the anti-androgen group barely lost any fat at all – the role of androgens in fat loss is clearly demonstrated. Even more impressive, the nandrolone group actually gained an average of roughly four pounds of lean mass in spite of the calorie restriction while the placebo and anti-androgen groups lost over two pounds of lean mass. Nandrolone also did not produce insulin resistance as androgens have been previously believed to do.
The role of testosterone on skin condition is often ignored, even though this should be of obvious concern to anybody using testosterone to improve overall physical appearance. Normally it is believed that testosterone can only worsen skin by causing breakouts of acne. However, low testosterone levels can only lead to worsening of skin conditions as well. Restoring testosterone to normal levels can make skin look much thicker and smoother than it was before.
En ole (tietääkseni) nainen, mutta apteekkitavarana myyty Vichyn Homme -kasvovoide joka vaikuttaa myös ihon testosteronipitoisuuksiin on tehnyt ihmeitä kasvojen ihon laadulle jo lyhyessä ajassa. Kantsiskohan naistenkin kokeilla?
PS: Kannattaa ehdottomasti myös lukea kirjoittajan The Sequel, estrogeeni & progesteronihoitoja miehille!
Pretending to be certain about propositions for which no evidence is even conceivable—is both an intellectual and a moral failing. —Sam Harris