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jussipussi
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Viestejä47461

  Vahvoja syitä tutkia laajemminkin.

Oral magnesium supplementation improves glycaemic status in subjects with prediabetes and hypomagnesaemia: A double-blind placebo-controlled randomized trial.

Abstract AIM:

This study evaluated the efficacy of oral magnesium supplementation in the reduction of plasma glucose levels in adults withprediabetes and hypomagnesaemia.

METHODS:

A total of 116 men and non-pregnant women, aged 30 to 65years with hypomagnesaemia and newly diagnosed withprediabetes, were enrolled into a randomized double-blind placebo-controlled trial to receive either 30mL of MgCl2 5% solution (equivalent to 382mg of magnesium) or an inert placebo solution once daily for four months. The primary trial endpoint was the efficacy of magnesium supplementation in reducing plasma glucose levels.

RESULTS:

At baseline, there were no significant statistical differences in terms of anthropometric and biochemical variables between individuals in the supplement and placebo groups. At the end of follow-up, fasting (86.9±7.9 and 98.3±4.6mg/dL, respectively; P=0.004) and post-load glucose (124.7±33.4 and 136.7±23.9mg/dL, respectively; P=0.03) levels, HOMA-IR indices (2.85±1.0 and 4.1±2.7, respectively; P=0.04) and triglycerides (166.4±90.6 and 227.0±89.7, respectively; P=0.009) were significantly decreased, whereas HDL cholesterol (45.6±10.9 and 46.8±9.2mg/dL, respectively; P=0.04) and serum magnesium (1.96±0.27 and 1.60±0.26mg/dL, respectively; P=0.005) levels were significantly increased in those taking MgCl2 compared with the controls. A total of 34 (29.4%) people improved their glucose status (50.8% and 7.0% in the magnesium and placebo groups, respectively; P<0.0005).

CONCLUSION:

Our results show that magnesium supplementation reduces plasma glucose levels, and improves the glycaemic statusof adults with prediabetes and hypomagnesaemia.

http://www.ncbi.nlm.nih.gov/pubmed/25937055

jussipussi
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Viestejä47461

Assosiaatioita.

Dietary intake of calcium and magnesium and the metabolic syndrome in the National Health and Nutrition Examination (NHANES) 2001-2010 data.

Abstract

 

Higher dietary intakes of Mg and Ca, individually, have been associated with a decreased risk for the metabolic syndrome (MetSyn). Experimental studies suggest that a higher intra-cellular ratio of Ca:Mg, which may be induced by a diet high in Ca and low in Mg, may lead to hypertension and insulin resistance. However, no previous epidemiological studies have examined the effects of the combined intake of Mg and Ca on MetSyn. Thus, we evaluated the association between dietary intakes of Ca and Mg (using 24-h recalls), independently and in combination, and MetSyn in the National Health and Nutrition Examination Study 2001-2010 data, which included 9148 adults (4549 men and 4599 women), with complete information on relevant nutrient, demographic, anthropometric and biomarker variables. We found an inverse association between the highest (>355 mg/d) v. the lowest (<197 mg/d) quartile of Mg and MetSyn (OR 0·70; 95 % CI 0·57, 0·86). Women who met the RDA for both Mg (310-320 mg/d) and Ca (1000-1200 mg/d) had the greatest reduced odds of MetSyn (OR 0·59; 95 % CI 0·45, 0·76). In men, meeting the RDA for Mg (400-420 mg/d) and Ca (1000-1200 mg/d), individually or in combination, was not associated with MetSyn; however, men with intakes in the highest quartile for Mg (≥386 mg/d) and Ca (≥1224 mg/d) had a lower odds of MetSyn (OR 0·74; 95 % CI 0·59, 0·93). Our results suggest that women who meet the RDA for Mg and Ca have a reduced odds of MetSyn but men may require Ca levels higher than the RDA to be protected against MetSyn.

http://www.ncbi.nlm.nih.gov/pubmed/26259506

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Vierailija

https://fi.wikipedia.org/wiki/Magnesium

Valtion ravitsemusneuvottelukunnan suositus naisilla on keskimäärin noin 280 mg/vrk, miehillä 350 mg/vrk. Lapsilla tarve on pienempi ja riippuu iästä.[6] Työikäiset suomalaiset saavat magnesiumia keskimäärin noin 340 mg/vrk (naiset) ja 428 mg/vrk
(miehet), nuoret enemmän kuin vanhat.[7]. Hyviä magnesiumin lähteitä ovat täysjyvävilja, kasvikset, kala ja liha.

 Wikin mukaan suomessa magnesiumia saadaan tarpeeksi.

Pumpkin seed    535.0mg per 100g

Cocoa powder, unsweetened    520.0

Sunflowerseed    355.0

Soy protein concentrate, 58% protein    315.0

Almond    278.0

Chocolate plain 80 %    260.0

Cashew nut    260.0

Porsaankyljys, grillattu    30.0

 Eli, siemenet, pähkinät, kokojyväviljatuotteet, riisi jne. 500mg saa ihan normaalista ravinnosta jos syö täyjyväleipää ja viljatuoteita sekä n.200g lihaa. Siinä tosin tulee kaikkea muutakin tarvittavaa. Jos on huonolla ravinnolla ja alkoholisti niin varmaan kannattaa harkita jotain multivitamiinin ottamista myöskin.

jussipussi
Seuraa 
Viestejä47461
SamikoKu

https://fi.wikipedia.org/wiki/Magnesium

Valtion ravitsemusneuvottelukunnan suositus naisilla on keskimäärin noin 280 mg/vrk, miehillä 350 mg/vrk. Lapsilla tarve on pienempi ja riippuu iästä.[6] Työikäiset suomalaiset saavat magnesiumia keskimäärin noin 340 mg/vrk (naiset) ja 428 mg/vrk
(miehet), nuoret enemmän kuin vanhat.[7]. Hyviä magnesiumin lähteitä ovat täysjyvävilja, kasvikset, kala ja liha.

 Wikin mukaan suomessa magnesiumia saadaan tarpeeksi.

Tässä uudempaa listausta ja luvuissa on myös mukana lisäravinteita nauttivat.

Finravinto 2012 -tutkimus The National FINDIET 2012 Survey

Taulukko 5.13. Vitamiini ja kivennäisainevalmisteita käyttävien osuus sekä vitamiinien ja kivennäisaineiden keskimääräinen (keskihajonta) päivittäinen saanti ravintolisistä ravintoaineittain ja sukupuolittain.

Sivu 99

https://www.julkari.fi/bitstream/handle/10024/110839/THL_RAP2013_016_%26sliitteet.pdf?sequence=1

Vomies
Seuraa 
Viestejä2888

Venäläiset tilasivat meiltä oikeastaan ainoina magnesiumin mittausmahdollisuuden. Luulen, että koska siellä juodaan paljon ja alkoholi kuluttaa magnesiumia.

Vaka vanha Väinämöinen, tietäjä iänikuinen.

jussipussi
Seuraa 
Viestejä47461

Assosiaatio.

"Magnesium intake may be beneficial in preventing pancreatic cancer

Pancreatic cancer is really unique and different from other cancers," said study co-author Ka He, chair of the Department of Epidemiology and Biostatistics at the IU School of Public Health-Bloomington. "The five-year survival rate is really low, so that makes prevention and identifying risk factors or predictors associated with pancreatic cancer very important."

Previous studies have found that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. But few studies have explored the direct association of magnesium with pancreatic cancer; of those that did, their findings were inconclusive, said Daniel Dibaba, a Ph.D. student at the School of Public Health-Bloomington, who led the IU study.

Using information from the VITamins and Lifestyle study, Dibaba and the other co-authors analyzed an enormous trove of data on over 66,000 men and women, ages 50 to 76, looking at the direct association between magnesium and pancreatic cancer and whether age, gender, body mass index, non-steroidal anti-inflammatory drugs use and magnesium supplementation play a role.

Of those followed, 151 participants developed pancreatic cancer. The study found that every 100-milligrams-per-day decrease in magnesium intake was associated with a 24 percent increase in the occurrence of pancreatic cancer. The study also found that the effects of magnesium on pancreatic cancer did not appear to be modified by age, gender, body mass index or non-steroidal anti-inflammatory drug use, but was limited to those taking magnesium supplements either from a multivitamin or individual supplement.

"For those at a higher risk of pancreatic cancer, adding a magnesium supplement to their diet may prove beneficial in preventing this disease," Dibaba said. "While more study is needed, the general population should strive to get the daily recommendations of magnesium through diet, such as dark, leafy greens or nuts, to prevent any risk of pancreatic cancer."

http://www.sciencedaily.com/releases/2015/12/151218161439.htm

jussipussi
Seuraa 
Viestejä47461

Kuopiosta.

Assosiaatioita magnesiumin saannin ja masennuksen välillä. Vihjeitä myös siihen että sopiva määrä on parempi kuin liikaa.

"Highlights

•Dietary magnesium intake was found to have an association with the risk of depression.
•This is the first prospective study with 20 years of follow-up to report the association between magnesium intake and the incidence of depression in men.
•Further studies need to clarify if magnesium has a role in prevention of depression.

Abstract
Background

Depression is a major global public health concern. The aetiology of depression is partly unclear; however, intake of nutrients, such as magnesium, have been suggested to affect depressive symptoms and modify depression risk.

Methods

This research is a part of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) Study, conducted on a sample of 2320 Eastern Finnish men aged 42–61 years old at the baseline. Magnesium intake was assessed by a 4-day food record. Hospital discharge diagnosis of unipolar depressive disorder was used as an outcome variable.

Results

Participants in the middle tertile of dietary magnesium intake had a statistically significantly decreased risk of getting a hospital discharge diagnosis of depression compared to participants in the lowest tertile of magnesium intake (HR 0.49, CI 0.25–0.95, P=0.035) in the prospective setting after multivariable adjustments. In addition, an inverse association between magnesium intake and the risk of depression was found when the combined middle and highest tertiles of magnesium intake were compared with the lowest tertile (HR 0.53, CI 0.29–0.95, P=0.033).

Limitations

Our findings may not be generalizable to individuals below middle-age or women. Moreover, we were unable to consider cases with mild depression in the longitudinal setting.

Conclusions

The results of this study suggest that magnesium intake may have an effect on the risk to develop depression. Further studies are needed to investigate whether sufficient magnesium intake could have implications for prevention or treatment of depression."

http://www.jad-journal.com/article/S0165-0327%2815%2931182-4/abstract

Diam
Seuraa 
Viestejä2808

Tein aamulla ihmiskokeen ja huomasin, että Mg on kahvin vastavaikuttaja. Se ilmeisesti oikeasti poistaa kortisolia hippokampuksesta. Onkohan muita tällaisia relaxantteja ilman reseptiä.

Mies kysyi kaiulta: Ostanko Nuhvin vai Majorin? ja kaiku vastasi: VAI MAJORIN!

jussipussi
Seuraa 
Viestejä47461

Laadukasta Meta-analyysiä, magnesium ja verenpaine.

Effects of Magnesium Supplementation on Blood Pressure

A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials

Abstract

The antihypertensive effect of magnesium (Mg) supplementation remains controversial. We aimed to quantify the effect of oral Mg supplementation on blood pressure (BP) by synthesizing available evidence from randomized, double-blind, placebo-controlled trials. We searched trials of Mg supplementation on normotensive and hypertensive adults published up to February 1, 2016 from MEDLINE and EMBASE databases; 34 trials involving 2028 participants were eligible for this meta-analysis. Weighted mean differences of changes in BP and serum Mg were calculated by random-effects meta-analysis. Mg supplementation at a median dose of 368 mg/d for a median duration of 3 months significantly reduced systolic BP by 2.00 mm Hg (95% confidence interval, 0.43–3.58) and diastolic BP by 1.78 mm Hg (95% confidence interval, 0.73–2.82); these reductions were accompanied by 0.05 mmol/L (95% confidence interval, 0.03, 0.07) elevation of serum Mg compared with placebo. Using a restricted cubic spline curve, we found that Mg supplementation with a dose of 300 mg/d or duration of 1 month is sufficient to elevate serum Mg and reduce BP; and serum Mg was negatively associated with diastolic BP but not systolic BP (all P<0.05). In the stratified analyses, a greater reduction in BP tended to be found in trials with high quality or low dropout rate (all P values for interaction <0.05). However, residual heterogeneity may still exist after considering these possible factors. Our findings indicate a causal effect of Mg supplementation on lowering BPs in adults. Further well-designed trials are warranted to validate the BP-lowering efficacy of optimal Mg treatment."

http://hyper.ahajournals.org/content/68/2/324.long

jussipussi
Seuraa 
Viestejä47461

"Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials.

Abstract

Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mgsupplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementationon glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mgsupplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies; other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (n=334), Mg treatment (n=336) reduced fasting plasma glucose (studies=9; SMD=-0.40; 95% CI: -0.80 to -0.00; I2=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants),

Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=-0.35; 95% CI: -0.62 to -0.07; I2=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=-0.57; 95% CI: -1.17 to 0.03; I2=88%).

Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes."

http://www.ncbi.nlm.nih.gov/pubmed/27530471

jussipussi
Seuraa 
Viestejä47461

"A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control.

Abstract

A systematic review and meta-analysis was conducted to evaluate the effect of oral magnesium supplementation on insulin sensitivity and glucose control in both diabetic and non-diabetic individuals. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to November 25, 2015) to identify RCTs evaluating the effect ofmagnesium on insulin sensitivity and glucose control. A random-effects model and generic inverse variance method were used to compensate for the heterogeneity of studies. Publication bias, sensitivity analysis, and meta-regression assessments were conducted using standard methods. The impact of magnesium supplementation on plasma concentrations of glucose, glycated hemoglobin (HbA1c), insulin, and HOMA-IR index was assessed in 22, 14, 12 and 10 treatment arms, respectively. A significant effect of magnesium supplementation was observed on HOMA-IR index (WMD: -0.67, 95% CI: -1.20, -0.14, p=0.013) but not on plasma glucose (WMD: -0.20mmol/L, 95% CI: -0.45, 0.05, p=0.119), HbA1c (WMD: 0.018mmol/L, 95% CI: -0.10, 0.13, p=0.756), and insulin (WMD: -2.22mmol/L, 95% CI: -9.62, 5.17, p=0.556). A subgroup analysis comparing magnesium supplementation durations of <4 months versus ≥4 months, exhibited a significant difference for fasting glucose concentrations (p<0.001) and HOMA-IR (p=0.001) in favor of the latter subgroup. 

Magnesium supplementation for ≥4 months significantly improves the HOMA-IR index and fasting glucose, in both diabetic and non-diabetic subjects. The present findings suggest that magnesium may be a beneficial supplement in glucose metabolic disorders."

http://www.ncbi.nlm.nih.gov/pubmed/27329332

jussipussi
Seuraa 
Viestejä47461

Meta-analyysiä. Ravinnon magnesium, Assosiaatiot.

"A diet rich in magnesium may reduce the risk of diseases including coronary heart disease, stroke and type-2 diabetes according to a new meta-analysis published in the open access journal BMC Medicine.

This analysis of the evidence on dietary magnesium and health outcomes is the largest to date, involving data from more than one million people across nine countries.

The researchers, from Zhejiang University and Zhengzhou University in China, found that people in the highest category of dietary magnesium consumption had a 10% lower risk of coronary heart disease, 12% lower risk of stroke and a 26% lower risk of type-2 diabetes compared to those in the lowest category.

Their results also indicate that an extra 100mg per day of dietary magnesium could also reduce risk of stroke by 7% and type-2 diabetes by 19%.

Dr Fudi Wang, lead author from the School of Public Health at Zhejiang University, said: "Low levels of magnesium in the body have been associated with a range of diseases but no conclusive evidence has been put forward on the link between dietary magnesium and health risks. Our meta-analysis provides the most up-to-date evidence supporting a link between the role of magnesium in food and reducing the risk of disease.""

http://medicalxpress.com/news/2016-12-dietary-magnesium-heart-disease-di... .

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