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jussipussi
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Himuli kirjoitti:
Olen kuullut puhuttavan jostain vitamin-c complexista, onko se höpö juttuja? Ajatuksena että c-vitamiiniin kuuluisi luontaisesti useita muitakin aineita samaan pakettiin, jotka lisäravinnemuotoisesta c-vitamiinista on jätetty pois johtaen niiden huonompaan tehoon tai jopa kielteisiin vaikutuksiin suuremmilla annoksilla. Jotkut sitten kaupittelevat noita "complexeja" kovaan hintaan. 
Jos haluaa asiaa selvittää niin ensin katsoo mitä niissä "complekseissa" on aineosia ja sitten käy läpi mahdolliset metra-analyysit näiden aineden osalta. Siitä saa jo kohtuullisen näkemyksen asiasta. 

jussipussi
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Himuli kirjoitti:
Eikös tupakka ja sokeri olleet c-vitamiinille ilkeitä.. 
Tupakoitsijoille suositellaan suurempaa annosta C.tä. C on niiden tupakan satojen myrkkyjen kimpussa, kuluu C.tä siinä painissa enemmän.

Sokeri ja C vitamiini on rakenteeltaan hyvin samankaltaisia siksi keho käyttää glukoosin transportteria GLUT 1  sekä sokerin että C-vitamiiinin siirtoon soluun. Sillä erotuksella että insuliini portsarina päästää soittoruokalaan(soluun) sokerin ensin joten C voi jäädä hieman pidempää ovelle jonottamaan. 

"GLUT1 is responsible for the low level of basal glucose uptake required to sustain respiration in all cells. Expression levels of GLUT1 in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels.[citation needed]

GLUT1 is also a major receptor for uptake of Vitamin C as well as glucose, especially in non vitamin C producing mammals as part of an adaptation to compensate by participating in a Vitamin C recycling process. In mammals that do produce Vitamin C, GLUT4 is often expressed instead of GLUT1.[7]"

https://en.wikipedia.org/wiki/GLUT1 -

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jussipussi
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Keijona kirjoitti:
"Tulokset paljastivat lopulta miehen kärsivän vakavasta hepatiitista eli maksatulehduksesta.

http://www.mtv.fi/lifestyle/makuja/artikkeli/mies-joi-liki-sata-energiaj... .

 

Professori, ylilääkäri Martti Färkkilä kertoo 

- Yhteys energiajuomien ja maksa-arvojen kohoamisen välillä on hyvin tunnettu. Energiajuomat, limsat ja nimenomaan light-juomat, joissa on makeutusaineena paljon fruktoosia ja aspartaamia, aiheuttavat rasvamaksan, Färkkilä sanoo.

- Kyse on erittäin tavallisesta ilmiöstä. Näiden juomien runsas käyttö johtaa lähes poikkeuksetta rasvamaksan kehittymiseen.

Färkkilän mukaan korrelaatio on jatkuva. Mitä enemmän limsoja ja energiajuomia juo, sitä enemmän tulee kaloreita, ja maksan rasvoittumisriski on suurempi. Kevytjuomissa käytetään makeutusaineena aspartaamia, jonka on osoitettu lisäävän maksarasvan riskiä ja vaikuttavan myös painonnousuun.

”Yli puoli litraa energiajuomia ja limsoja päivässä on jo liikaa.”

https://www.uusisuomi.fi/kotimaa/98571-energiajuomat-varo-rasvamaksaa .

https://fi.wikipedia.org/wiki/Rasvamaksa

"Suomalaisten maksat ovat huonossa kunnossa – syynä viina ja nopeat sokerit"

http://www.hs.fi/kotimaa/art-2000002720008.html

Vilkaistaan sitten miten mahdollisesti C-vitamiini suhteutuu maksan rasvoittumiseen.

Korrelaatio.

"Association between Dietary Vitamin C Intake and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Middle-Aged and Older Adults.

 The relative odds of NAFLD was decreased by 0.71 times in the fourth quartile of dietary vitamin C intake compared with the lowest quartile. 

CONCLUSION:

There might be a moderate inverse association between dietary vitamin C intake and NAFLD in middle-aged and older adults, especially for the male population and non-obesity population."

https://www.ncbi.nlm.nih.gov/pubmed/26824361 .

"Does vitamin C deficiency promote fatty liver disease development?

 Large epidemiological studies and findings from controlled in vivo animal studies have provided evidence supporting an association between poor vitamin C (VitC) status and propagation of life-style associated diseases. In addition, overweight per se has been shown to result in reduced plasma VitC, and the distribution of body fat in obesity has been shown to have an inverse relationship with VitC plasma levels. Recently, a number of epidemiological studies have indicated a VitC intake below the recommended daily allowance (RDA) in NAFLD-patients, suggesting an association between dietary habits, disease and VitC deficiency. In the general population, VitC deficiency (defined as a plasma concentration below 23 μM) affects around 10% of adults, however, this prevalence is increased by an adverse life-style, deficiency potentially playing a broader role in disease progression in specific subgroups. 

https://www.ncbi.nlm.nih.gov/pubmed/25533004

Associations between intakes of individual nutrients or whole food groups and non-alcoholic fatty liver disease among Korean adults.

 In men, after adjusting for variables, low intakes of vitamin C (odds ratio [OR], 4.23), 

CONCLUSIONS:

Adequate intakes of vitamin C, vitamin K, folate, omega-3 fatty acids, nuts and seeds, and vegetables may help in preventing NAFLD in Korean adults."

https://www.ncbi.nlm.nih.gov/pubmed/24955455

Tästä toki voisi kaivaa enemmänkin ja katsoa tarkemmin tuota sokerien ja C-vitamiinin "kilpailuasetelmaa" kropassa / soluissa.

Tässä pieni näyte C-vitamiinin transporttereiden ja  Maksan ongelmien osalta.

https://www.ncbi.nlm.nih.gov/pubmed/23708151 .

jussipussi
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Tehdään OT hyppy B vitamiineihin kun globaalisti tarkasteltuna alla oleva saattaa olla merkittävä löydös.

"B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

Significance

Air pollution is a major public health concern worldwide. The molecular mechanistic underpinnings of the health effects of air pollution are not fully understood, and the lack of individual-level preventative options represent a critical knowledge gap. Our study demonstrated the epigenetic effects of air pollution and suggested that B vitamins might be used as prevention to complement regulations to attenuate the impact of air pollution on the epigenome. Our study inaugurated a line of research for the development of preventive interventions to minimize the adverse effects of air pollution on potential mechanistic markers. Because of the central role of epigenetic modifications in mediating environmental effects, our findings might be extended to other toxicants and environmental diseases.

Abstract

Acute exposure to fine particle (PM2.5) induces DNA methylation changes implicated in inflammation and oxidative stress. We conducted a crossover trial to determine whether B-vitamin supplementation averts such changes. Ten healthy adults blindly received a 2-h, controlled-exposure experiment to sham under placebo, PM2.5 (250 μg/m3) under placebo, and PM2.5 (250 μg/m3) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12), respectively. We profiled epigenome-wide methylation before and after each experiment using the Infinium HumanMethylation450 BeadChip in peripheral CD4+ T-helper cells. PM2.5 induced methylation changes in genes involved in mitochondrial oxidative energy metabolism.

B-vitamin supplementation prevented these changes. 

Likewise, PM2.5 depleted 11.1% [95% confidence interval (CI), 0.4%, 21.7%; P = 0.04] of mitochondrial DNA content compared with sham, and B-vitamin supplementation attenuated the PM2.5 effect by 102% (Pinteraction = 0.01).

Our study indicates that individual-level prevention may be used to complement regulations and control potential mechanistic pathways underlying the adverse PM2.5 effects, with possible significant public health benefit in areas with frequent PM2.5 peaks."

http://www.pnas.org/content/early/2017/03/07/1618545114 .

.

Taking B vitamins may reduce epigenetic effects of air pollution

https://medicalxpress.com/news/2017-03-vitamins-epigenetic-effects-air-p... .

jussipussi
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jussipussi kirjoitti:

Taking B vitamins may reduce epigenetic effects of air pollution

https://medicalxpress.com/news/2017-03-vitamins-epigenetic-effects-air-p... .

Dataa.

"Ilmansaasteet tappavat ennenaikaisesti – Katso täältä 11 vinkkiä raikkaampaan arkeen

Noin 1 800 suomalaista kuolee ennenaikaisesti ilmansaasteisiin vuosittain. Pahimpia pienhiukkasten lähteitä ovat liikenne ja kotien tulipesät. Lue asiantuntijoiden vinkit, miten voit itse vaikuttaa hengitysilmaasi kotona ja liikenteessä."

http://yle.fi/uutiset/3-8933512

jussipussi
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Nostetaan tämä vielä erikseen esille.

"Pienhiukkaset ovat isoin kuolleisuuteen vaikuttava ympäristötekijä"

Helsingin seudun ympäristöpalvelujen HSY:n ilmansuojeluasiantuntijan Anu Kousan mukaan liikenteen aiheuttamat pienhiukkaset ovat vakavin ympäristöön liittyvä terveysriski.

– Kun esimerkiksi radonia, melua ja pienhiukkasia verrataan, niin pienhiukkaset ovat isoin kuolleisuuteen vaikuttava ympäristötekijä.

Kousan mielestä liikenteen päästöihin tulisi kiinnittää enemmän huomiota, sillä niihin kuolee enemmän ihmisiä kuin liikeneonnettomuuksissa."

http://yle.fi/uutiset/3-8933512 .

Nalle
Seuraa 
Viestejä2

Noin pari vuotta sitten oli lehdissä artikkeleita joissa kerrottiin C-vitamiinin tehoavan (suonen sisäisesti) syöpäkasvaimiin.

Noihin tutkimuksiin viitaten, Suomessa(kin) voitaisiin kokeilla C-vitamiinia suoneen syövän tukihoitona, vaikka syöpäleikkausjonossa odottaville potilaille. Olisiko tämä liian halpa hoitomuoto, kun USA:ssa näkyy hoitokerran hinta olevan vain 120-150$. Halpa hinta karkottaa yleensä tutkimuksen rahoittajat ja ilman tutkittua tietoa uusia hoitomuotoja on mahdoton ottaa käyttöön.

jussipussi
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"Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial

Abstract

Background

We aimed to investigate the efficacy of ascorbic acid and acetylsalicylic acid among type II diabetes mellitus patients using metformin (only) for diabetes management therapy.

Method

A 12-month single blinded multicenter randomized control trial was designed to investigate the measured variables [Glycated Hemoglobin (HbA1c), Renal function, Albumin Creatinine Ratio (ACR) etc.]. The trial was randomized into 2 experimental parallel arms (ascorbic acid vs acetylsalicylic acid) were blinded with study supplements in combination with metformin and findings were compared to control arm with metformin alone and blinded with placebo. Withdrawal criteria was defined to maintain the equity and balance in the participants in the whole trial.

Finding

Patients with metformin and ascorbic acid (parallel arm I) was twice more likely to reduce HbA1c than metformin alone (control arm) in a year (OR 2.31 (95% CI 1.87–4.42) p < 0.001). Also Parallel arm I was ten times more likely to reduced risk factors contributing to long-term diabetes complications than participants of arm II in a year (OR 10.38 (95% CI 6.91–15.77) p < 0.001). In contrast, parallel arm II patients were seven times more effective to reduce the risk of expected CVD development in 10 years than arm I (OR 7.54 (95% CI 3.76–10.32) p < 0.001).

Conclusions

The trial concluded that ascorbic acid with metformin is more effective against reducing risks for diabetes related long-term complications (including ACR)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556597/ .

jussipussi
Seuraa 
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"Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia.

"We have known for a while that people with lower levels of ascorbate (vitamin C) are at increased cancer risk, but we haven't fully understood why. Our research provides part of the explanation, at least for the blood-forming system," said Dr. Sean Morrison, the Director of CRI.

"Stem cells use ascorbate to regulate the abundance of certain chemical modifications on DNA, which are part of the epigenome," said Dr. Michalis Agathocleous, lead author of the study, an Assistant Instructor at CRI, and a Royal Commission for the Exhibition of 1851 Research Fellow. "The epigenome is a set of mechanisms inside a cell that regulates which genes turn on and turn off. So when stem cells don't receive enough vitamin C, the epigenome can become damaged in a way that increases stem cell function but also increases the risk of leukemia."

This increased risk is partly tied to how ascorbate affects an enzyme known as Tet2, the study showed. Mutations that inactivate Tet2 are an early step in the formation of leukemia. CRI scientists showed that ascorbate depletion can limit Tet2 function in tissues in a way that increases the risk of leukemia.

These findings have implications for older patients with a common precancerous condition known as clonal hematopoiesis. This condition puts patients at a higher risk of developing leukemia and other diseases, but it is not well understood why certain patients with the condition develop leukemia and others do not. The findings in this study might offer an explanation.

"One of the most common mutations in patients with clonal hematopoiesis is a loss of one copy of Tet2. Our results suggest patients with clonal hematopoiesis and a Tet2 mutation should be particularly careful to get 100 percent of their daily vitamin C requirement," Dr. Morrison said. "Because these patients only have one good copy of Tet2 left, they need to maximize the residual Tet2 tumor-suppressor activity to protect themselves from cancer.""

https://medicalxpress.com/news/2017-08-scientists-vitamin-stem-cell-func... .

jussipussi
Seuraa 
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"Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study.

Abstract

BACKGROUND:

Antioxidants like vitamins C and E may minimize the risk for Alzheimer's disease.

OBJECTIVE:

We examined whether vitamins C and E modify the apolipoprotein E (APOE) E4-related risks for developing cognitive decline.

METHODS:

We conducted a population-based prospective study including Japanese residents aged 65 years from Nakajima, Japan. The participants received an evaluation of cognitive function and underwent blood tests including tests for vitamins C and E levels and APOE phenotypes. The APOE E4-by-gender-by-vitamin C or E interactions on developing cognitive decline were analyzed.

RESULTS:

Of 606 participants with normal cognitive function determined using a baseline survey (2007-2008), 349 completed the follow up survey between 2014 and 2016. In women with APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin C concentration tertile [multivariate OR 0.10 (95% CI 0.01-0.93)] compared with the lowest tertile. In men without APOE E4, significantly reduced risk for cognitive decline was observed for the highest blood vitamin E concentration tertile [multivariate OR 0.19 (0.05-0.74)] as compared with the lowest tertile.

CONCLUSION:

Our results demonstrate significant beneficial effects of vitamins C and E in reducing the risk of cognitive decline in women with APOE E4 and men without APOE E4, respectively."

https://www.ncbi.nlm.nih.gov/pubmed/29758939 .

.

Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid.

Abstract

More than 30 human degenerative diseases result from protein aggregation such as Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). Islet amyloid deposits, a hallmark in T2DM, are found in pancreatic islets of more than 90 % of T2DM patients. An association between amylin aggregation and reduction in β-cell mass was also established by post-mortem studies. A strategy in preventing protein aggregation-related disorders is to inhibit the protein aggregation and associated toxicity. In this study we demonstrated that two inhibitors, lipoic acid and ascorbic acid, significantly inhibited amylin aggregation. Compared to amylin (15 μM) as 100 %, lipoic acid and ascorbic acid reduced amylin fibril formation to 42.1 ± 17.2 % and 42.9 ± 12.8 % respectively, which is confirmed by fluorescence and TEM images. In cell viability tests, both inhibitors protected RIN-m5f β-cells from the toxicity of amylin aggregates. At 10:1 molar ratio of lipoic acid to amylin, lipoic acid with amylin increased the cell viability to 70.3 %, whereas only 42.8 % RIN-m5f β-cells survived in amylin aggregates. For ascorbic acid, an equimolar ratio achieved the highest cell viability of 63.3 % as compared to 42.8 % with amylin aggregates only. Docking results showed that lipoic acid and ascorbic acid physically interact with amylin amyloidogenic region (residues Ser20-Ser29) via hydrophobic interactions; hence reducing aggregation levels. Therefore, lipoic acid and ascorbic acid prevented amylin aggregation via hydrophobic interactions, which resulted in the prevention of cell toxicity in vitro.

https://www.ncbi.nlm.nih.gov/pubmed/29758939 .

jussipussi
Seuraa 
Viestejä52104

"APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921.

Abstract

Carriers of the APOE E4 allele have an increased risk of developing Alzheimer's disease. However, it is less clear whether APOE E4 status may also be involved in non-pathological cognitive ageing. The present study investigated the associations between APOE genotypes and cognitive change over 8 years in older community-dwelling individuals. APOE genotype was determined in 501 participants of the Lothian Birth Cohort 1921, whose intelligence had been measured in childhood in the Scottish Mental Survey 1932. A polymorphic variant of TOMM40 (rs10524523) was included to differentiate between the effects of the APOE E3 and E4 allelic variants. Cognitive performance on the domains of verbal memory, abstract reasoning and verbal fluency was assessed at mean age 79 years (n=501), and again at mean ages of 83 (n=284) and 87 (n=187). Using linear mixed models adjusted for demographic variables, vascular risk factors and IQ at age 11 years, possession of the APOE E4 allele was associated with a higher relative rate of cognitive decline over the subsequent 8 years for verbal memory and abstract reasoning. Individuals with the long allelic variant of TOMM40, which is linked to APOE E4, showed similar results. Verbal fluency was not affected by APOE E4 status. APOE E2 status was not associated with change in cognitive performance over 8 years. In non-demented older individuals, possession of the APOE E4 allele predicted a higher rate of cognitive decline on tests of verbal memory and abstract reasoning between 79 and 87 years. Thus, possession of the APOE E4 allele may not only predispose to Alzheimer's disease, but also appears to be a risk factor for non-pathological decline in verbal memory and abstract reasoning in the ninth decade of life."

https://www.ncbi.nlm.nih.gov/pubmed/21263443 .

jussipussi
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"Inhibition of Protein Aggregation by Several Antioxidants

Abstract

Amyloid fibril formation is a shared property of all proteins; therefore, model proteins can be used to study this process. We measured protein aggregation of the model amyloid-forming protein stefin B in the presence and absence of several antioxidants. 

Amyloid fibril formation by stefin B was routinely induced at pH 5 and 10% TFE, at room temperature. The effects of antioxidants NAC, vitamin C, vitamin E, and the three polyphenols resveratrol, quercetin, and curcumin on the kinetics of fibril formation were followed using ThT fluorescence. Concomitantly, the morphology and amount of the aggregates and fibrils were checked by transmission electron microscopy (TEM). The concentration of the antioxidants was varied, and it was observed that different modes of action apply at low or high concentrations relative to the binding constant. In order to obtain more insight into the possible mode of binding, docking of NAC, vitamin C, and all three polyphenols was done to the monomeric form of stefin B."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889867/ .

jussipussi
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."....To be specific, metabolites of vitamin C, which are generated in the aqueous solution, such as ascorbate anions and dehydroascorbic acid, can shield electrostatic interactions between β-sheets due to their specific interactions and cause disruption of β-sheet stacking. This mechanism is different from antioxidation, which is usually considered as a major mechanism of vitamin C action. It was even reported that it can decrease amyloid plaque burden in the cortex and hippocampus when tested on cross-bred mice [65]. In our study, it was confirmed once more that vit C has potential as an antiamyloid substance. However, at higher concentrations it may be less beneficial as it increases the most toxic higher oligomers."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889867/ .

.

"High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice.

Abstract

Blood-brain barrier (BBB) breakdown and mitochondrial dysfunction have been implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease characterized by cognitive deficits and neuronal loss. Besides vitamin C being as one of the important antioxidants, recently, it has also been reported as a modulator of BBB integrity and mitochondria morphology. Plasma levels of vitamin C are decreased in AD patients, which can affect disease progression. However, investigation using animal models on the role of vitamin C in the AD pathogenesis has been hampered because rodents produce with no dependence on external supply. Therefore, to identify the pathogenic importance of vitamin C in an AD mouse model, we cross-bred 5 familial Alzheimer's disease mutation (5XFAD) mice (AD mouse model) with ι-gulono-γ-lactone oxidase (Gulo) knockout (KO) mice, which are unable to synthesize their own vitamin C, and produced Gulo KO mice with 5XFAD mice background (KO-Tg). These mice were maintained on either low (0.66 g/l) or high (3.3 g/l) supplementation of vitamin C. We found that the higher supplementation of vitamin C had reduced amyloid plaque burden in the cortex and hippocampus in KO-Tg mice, resulting in amelioration of BBB disruption and mitochondrial alteration. These results suggest that intake of a larger amount of vitamin C could be protective against AD-like pathologies."

https://www.ncbi.nlm.nih.gov/pubmed/24577081/ .

Vierailija

Jonkun tutkimuksen innostamana joskus kymmenisen vuotta sitten laitoin C-vitamiinia vihreään teehen. Jostain syystä vihreän teen juonti kuitenkin on jäänyt vähemmälle.

jussipussi
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Mursu kirjoitti:
Hitler parani syövästä c-vitamiinin avulla ja siksi elää hyvävointisena Braziliassa

"Salaliittoteoriat murskaksi, asia on tutkittu: Hitler kuoli Berliinissä 1945 - ”Ei paennut sukellusveneellä eikä piileskele Kuussa”

Tutkijat saivat diktaattorin luujäänteet kunnolla tarkasteltavakseen ensi kertaa yli 70 vuoteen.

Natsi-Saksan johtajan ainoat jäljellä olevat jäänteet, leukaluu ja pala kallosta on tutkittu ensimmäisen kerran kunnolla.

Leukaluu kuuluu hammasanalyysin perusteella takuuvarmasti Hitlerille.

Tutkijoita auttoivat Hitlerin päästä 1944 otetut röntgenkuvat."

http://www.iltalehti.fi/ulkomaat/201805192200954873_ul.shtml  .

jussipussi
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jussipussi kirjoitti:
Suonensiäisesti annosteltu C on itsessään hyvin mielenkiintoinen aihe. Myrkytys, bakteeri ja viruskompikaatiot mahdollisina tutkimuskohteina.
High Dose Intraveneous Vitamin C and Chikungunya Fever: A Case Report. Abstract
The Chikungunya (CHIKV) fever is a viral disease produced by a single-stranded RNA Alphavirus from the Togaviridae genus. Its transmission occurs only through mosquito vectors, principally Aedes aegypti. It requires a human-mosquito-human transmission cycle. It is associated with severe arthritis/arthralgias, myalgias, high fever, headache, and maculopapular rash. Joint ache appears to be symmetrical. The virus has an incubation period of 2 to 7 days, where the high fever is typically presented. It is followed by arthralgias and myalgias, and rashes, which last for 3 to 5 days. However, the arthralgias can persist for months after the infection, which can contribute to severe arthritis. As of now, no vaccine exists for the virus and no official treatment has been developed aside from standard procedures of the use of acetaminophen (paracetamol), and non-steroidal anti-inflammatory drugs. This is a case report of a 54-year old Hispanic individual that reported left shoulder pain, left knee pain and fever. The symptoms started on a Saturday in September 2014 in middle of the night. The patient was treated with high doses of intravenous vitamin C over two days. The symptoms resolved after the infusions without any side effects. Based on the positive outcome in this case, we propose that intravenous vitamin C should be studied further as a potential treatment for acute viral infections.

"A simple vitamin cocktail to treat sepsis has shaken up the medical world, raising hopes of a more effective treatment for one of history’s great killers. But will it stand up to tougher tests?

Researchers at several hospitals around the world are trying to reproduce the success reported by a critical-care doctor in Virginia in beating back sepsis, one of the leading causes of hospital deaths.

The results got a lot of attention. But it was a small study, comparing before-and-after patient outcomes. Now, researchers are gearing up to test the therapy with large-scale trials using patients selected at random, with some given the cocktail and others given a placebo.

Survival often depends on an immediate dose of antibiotics and intravenous fluids, along with tests to look for signs of an infection or organ failure. Estimates of how much it costs to treat sepsis approach $24 billion a year.

Jarone Lee, MD, medical director of the intensive care unit at Massachusetts General Hospital, says finding a good treatment for sepsis would solve a lot of health care problems. ­

But it’s too early to declare victory without better data, says Lee, who is not involved in the ongoing trials.

“What I think we’re looking for is essentially hard science and great science about how this will work,” he says. “It doesn’t even have to show the amazing results like Paul did, just that we’re moving the needle forward and decreasing mortality or some other process measure that improves outcomes.”

Ambitious studies planned

Sevransky’s study plans to involve at least 500 and up to 2,000 patients at multiple hospitals for about a year and a half. The plan is to wrap up work in December 2019.

A second study, led by Michael Donnino, MD, at Harvard’s Beth Israel Deaconess Medical Center, involves about 200 patients and  a wider number of hospitals. It is expected to end in a year, says Ari Moskowitz, MD, a pulmonary care and critical care specialist at Beth Israel Deaconess.

Moskowitz says they hope the vitamin cocktail will  help limit injury to organs, such as the kidneys or heart. The study will evaluate how well it prevents organ injury along with survival rates. “Saving lives is the ultimate goal of the intervention,” he says.

Similar studies are underway in New Jersey, Slovenia, China, Australia, and Qatar.

The dose being studied is about 1.5 grams intravenously, every 6 hours for 4 days -- several times higher than people get from ordinary vitamin supplements or eating fruit, but less than some patients get while having chemotherapy, he said.

In a follow-up paper in April, Marik wrote that vitamin C lowers oxidative stress and inflammation, and it helps stop blood vessels from dilating, which helps maintain blood pressure. People who have sepsis often don't have enough vitamins C and B1, and those vitamins appear to combine with the steroid hydrocortisone to boost the effects.

“There is in fact an enormous amount of basic science to support this,” he says. An Australian study found that if Marik’s mixture works, it could shave more than 40% off the long-term cost of treating the disease.

“The bottom line is it saves billions of dollars and millions of life-years, and at worst, if it doesn’t work, all it does is waste a little bit of money and nothing is lost,” he says.

Sevransky says previous research has suggested vitamin C can improve blood flow to tissues in the body of a sepsis patient, keeping the cells supplied with nutrients and oxygen and preventing organ failure."

https://www.webmd.com/drug-medication/news/20180521/vitamin-cocktail-for... .

jussipussi
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jussipussi kirjoitti:
Suonensiäisesti annosteltu C on itsessään hyvin mielenkiintoinen aihe. Myrkytys, bakteeri ja viruskompikaatiot mahdollisina tutkimuskohteina.
 "Vitamin C may offer potential life-saving treatment for sepsis

Summary:

Physicians caring for patients with sepsis may soon have a new safe and cost-effective treatment for this life-threatening illness. Researchers have found that vitamin C can not only prevent the onset of sepsis, but can reverse the disease.

Sepsis is caused by a bacterial infection that can begin anywhere in your body. Your immune system goes into overdrive, overwhelming normal processes in your blood. The result is that small blood clots form, blocking blood flow to vital organs. This can lead to organ failure. Babies, the elderly and those with weakened immune systems are most likely to get sepsis. But even healthy people can become deathly ill from the disease.

According to Dr. Tyml, a professor at Western's Schulich School of Medicine & Dentistry, patients with severe sepsis have a high mortality rate, nearly 40 percent, because there is no effective treatment.

"Our research in mice with sepsis has found that early as well as delayed injections of vitamin C improves chance of survival significantly," explains Dr. Tyml. "Furthermore, the beneficial effect of a single bolus injection of vitamin C is long lasting and prevents capillary plugging for up to 24 hours post-injection."

Dr. Tyml and his colleagues are eager to find appropriate support to move this research from the bench to the bedside to see if these findings translate to patients with sepsis.

The potential benefit of this treatment is substantial. "Vitamin C is cheap and safe. Previous studies have shown that it can be injected intravenously into patients with no side effects," says Dr. Tyml. "It has the potential to significantly improve the outcome of sepsis patients world-wide. This could be especially beneficially in developing countries where sepsis is more common and expensive treatments are not affordable.""

https://www.sciencedaily.com/releases/2010/11/101117184457.htm  .

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