Seuraa 
Viestejä1246
Liittynyt10.12.2007

Nyt on kovaa ja uutta tietoa:

Kannabista käyttävät alttiita monille päihdeongelmille

Tulokset perustuvat kolmen vuoden välein tehtyihin väestökyselyihin, joihin osallistui 35 000 miestä ja naista. Ensimmäisessä kyselyssä 1 300 vastaajaa kertoi käyttävänsä kannabista.

Kannabista käyttävistä selvästi useammille kehittyi päihdeongelmia kolmen vuoden seurannan aikana. Verrattuna osallistujiin, jotka eivät käyttäneet kannabista, heille kehittyi kannabisriippuvuus lähes kymmenen kertaa todennäköisemmin.

http://www.tohtori.fi/?page=7743008&id=2954633

War doesn't determine who's right but who's left.

There is no such thing as an atheist in a foxhole.

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Kommentit (42)

Raisku
Seuraa 
Viestejä214
Liittynyt20.9.2015

Lääketieteellinen nollatutkimus-suomisanakirja:

"Kannabista käyttävät alttiita monille päihdeongelmille"

Päihdeongelmille alttiit saattavat käyttää myös kannabista.

"Verrattuna osallistujiin, jotka eivät käyttäneet kannabista, heille kehittyi kannabisriippuvuus lähes kymmenen kertaa todennäköisemmin."

Osa ihmisistä on riippuvaisia kannabiksesta, vaikka eivät olisi sitä koskaan edes nähnyt.

kuningas
Seuraa 
Viestejä1246
Liittynyt10.12.2007

Niin tuon voisi kai lausua myös:

"Joka kymmenes kannabisriippuvainen ei ole koskaan käyttänyt sitä."

War doesn't determine who's right but who's left.

There is no such thing as an atheist in a foxhole.

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

Assosiaatiotutkimus identtisillä kaksosilla.

"Early and frequent use of cannabis is associated with major depressive disorder (MDD) as well as suicidal thoughts and behaviors, a large twin study suggests.

Investigators led by Arpana Agrawal, PhD, associate professor of psychiatry, Washington University in St. Louis, found that among monozygotic twins, those who used cannabis were more than 100 times more likely to meet criteria for MDD and report suicidal ideation than their genetically identical twin who had never used cannabis or who had used it less frequently.

This finding held true when the researchers adjusted for covariates. However, occasional use of cannabis was not associated with MDD and suicidal thoughts or behaviors.

"We need to carefully evaluate the relationship between various levels of cannabis use, from casual to heavy and problematic, and serious mental health outcomes, like depression and suicidal thoughts and behaviors," Dr Agrawal told Medscape Medical News.

"We also need to examine all possible pathways that might lead to this association, such as shared genetic factors, and exclude them before ascribing causal effects," she said."

http://www.medscape.com/viewarticle/883614

http://thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30280-8/abstract

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

"A new study reveals a dampened physiological response to stress in chronic cannabis users. This is the first study to examine the effects of acute stress on salivary cortisol levels in chronic cannabis users compared to non-users.

"To the best of our knowledge, this is the first study to examine the effects of acute stress on salivary cortisol levels in chronic cannabis users compared to non-users," Cuttler said. "While we are not at a point where we are comfortable saying whether this muted stress response is a good thing or a bad thing, our work is an important first step in investigating potential therapeutic benefits of cannabis at a time when its use is spreading faster than ever before."

The WSU researchers found virtually no difference in the salivary cortisol levels of two groups of heavy cannabis users confronted with either a psychologically and physiologically stressful situation or a non-stressful one.

In contrast, cortisol levels among non-users of cannabis who experienced the same simulated stressful situation were found to be much greater than the cortisol level of non-users in the no-stress scenario.

The findings are consistent with a growing body of literature that indicates chronic cannabis use is associated with dulled adrenal and emotional reactivity. The study was published recently in the journal Psychopharmacology."

https://www.sciencedaily.com/releases/2017/07/170731090828.htm .

o_turunen
Seuraa 
Viestejä14016
Liittynyt16.3.2005

Voisiko ihminen olla kannabisriippuvainen, jos kannabista ei olisi olemassa?

Korant: Oikea fysiikka on oikeampaa kuin sinun klassinen mekaniikkasi. Jos olet eri mieltä kanssani olet ilman muuta väärässä.

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

o_turunen kirjoitti:
Voisiko ihminen olla kannabisriippuvainen, jos kannabista ei olisi olemassa?
Reseptorit löytyy ja erilaisia kannabinoideja.

"Chemical compounds called cannabinoids are found in marijuana and also are produced naturally in the body from omega-3 fatty acids. A well-known cannabinoid in marijuana, tetrahydrocannabinol, is responsible for some of its euphoric effects, but it also has anti-inflammatory benefits. A new study in animal tissue reveals the cascade of chemical reactions that convert omega-3 fatty acids into cannabinoids that have anti-inflammatory benefits - but without the psychotropic high."

https://www.sciencedaily.com/releases/2017/07/170718142909.htm .

"Eräät kannabinoideista ovat sisäsyntyisiä, kuten N-arakidonyylietanoliamiini eli anandamidi ja 2-arakidonyyliglyseroli eli 2-AG."

https://fi.wikipedia.org/wiki/Kannabinoidit .

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

Poistunut kirjoitti:
Mikähän olis tulos jos vertaisi alkoholisteihin?
Ajattele jos eläisimme sellaisessa maailmassa jossa saattaisi olla mhdollista löytää informaatiota tästä?

"Alcohol consumption and major depression: findings from a follow-up study.

Abstract

OBJECTIVE:

To investigate whether alcohol consumption predicts major depressive disorder episodes (MDEs) in the general population.

METHOD:

The respondents without depression (n = 12,290) in the longitudinal cohort of the Canadian National Population Health Survey (NPHS) were classified into cohorts based on any drinking, frequency of drinking, maximum number of drinks on a maximal drinking occasion, and average daily alcohol consumption, based on data collected in the 1994-1995 survey. Major depression frequency 2 years later, in 1996-1997, was evaluated and compared across drinking categories.

RESULTS:

The respondents who reported any drinking, drinking daily, having more than 5 drinks on a maximal drinking occasion, and having more than 1 drink daily on average, did not have an elevated risk of major depression. A trend in the data suggested that women who reported having more than 5 drinks on a maximal drinking occasion might be at a higher risk of major depression. No evidence of confounding or effect modification by demographic, psychological, and clinical variables was found.

CONCLUSION:

In a general population sample, alcohol consumption levels were not associated with major depression. Having more than 5 drinks on a maximal drinking occasion, however, may be associated with an increased risk of major depression among women. Extreme patterns of alcohol consumption, which tend to characterize clinical samples, are associated with depression. These patterns of drinking, however, are relatively uncommon in the general population, and the current analysis may have lacked power to detect these associations."

https://www.ncbi.nlm.nih.gov/pubmed/11582825 .

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

Excalibur kirjoitti:
Onhan sitä myös opioidireseptoreja...

Joka tapauksessa kannabisriippuvuus on myytti. 

Jenkeissä epidemia.

"Although opioid and heroin deaths have been rising dramatically in the U.S., the magnitude of the epidemic varies from state to state, as does the relative proportion of opioid vs heroin poisonings. Further complicating the picture is that up to one-quarter of all death certificates fail to note the specific drug responsible for the fatality, complicating efforts to target enforcement and treatment programs at both state and federal levels. A new study in the American Journal of Preventive Medicine presents a correction procedure to refine this data, which results in significant shifts in state-by-state mortality rates. This truer picture helps to remove an important barrier to formulating effective policies to address this serious drug epidemic."

https://medicalxpress.com/news/2017-08-accurate-state-opioid-heroin-fata... .

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

Alkoholi ja kannabis yhdessä. 

"The Bidirectional Relationships Between Alcohol, Cannabis, Co-occurring Alcohol and Cannabis Use Disorders with Major Depressive Disorder: Results From a National Sample

..Results

For Aim 1, most of the AUD and CUD were positively associated with MDD. The strongest associations with incident MDD were observed for cannabis dependence (OR=6.61, CI=1.67–26.21) and co-occurring alcohol and cannabis dependence (OR=2.34, CI=1.23–4.48). For Aim 2, baseline MDD was significantly associated with comparatively fewer cases of incident AUD and CUD but the strongest association was observed for new onset co-occurring alcohol and cannabis dependence (OR=4.51, CI=1.31–15.60)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608823/ .

jussipussi
Seuraa 
Viestejä40651
Liittynyt6.12.2009

Excalibur kirjoitti:
Onhan sitä myös opioidireseptoreja...

Joka tapauksessa kannabisriippuvuus on myytti. 

Joo ei.

"The strongest associations with incident MDD were observed for cannabis dependence (OR=6.61, CI=1.67–26.21) and co-occurring alcohol and cannabis dependence (OR=2.34, CI=1.23–4.48)."

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