Kommentit (8)

Käyttäjä4499
Seuraa 
Viestejä4410
Liittynyt21.7.2017

Jos asuisin maassa jossa kaljurottia, pyhittäisin niille oma pellon. :)

Ja jäisin varmaan ilman omia juureksia, sillä kaljurottayhdyskuntaan voi kuulua jopa satoja yksilöitä... Mut sulous ennen kaikkea. Bataatteja & kaljurottia, PEACE!

Organization of the Colony

The colony is ruled by the dominant female, or the queen. She is the only animal to breed. Her body becomes longer and larger once she becomes the queen, which enables her to contain more pups. If necessary, she fights to maintain her role in the colony.

The queen allows only two or three of the males to mate with her and is often said to give birth to up to twenty-seven pups at a time. The researcher in the video above says that the largest litter at Cornell contained thirty-three pups, however. The usual litter size is twelve to eighteen pups. The gestation period is about seventy days. The queen may breed four to five times a year, which helps the colony to become very large.

The other members of the colony are known as workers or soldiers. They have specific jobs, such as feeding and caring for the queen, taking care of the pups, digging tunnels, searching for food, and protecting the colony from enemies. They work as a group to fight predatory snakes.

It's interesting that the mole-rat colony has a social organization that resembles that of a bee colony. The rodents and the insects are very different animals, yet they have each developed a similar way of life.

Lähde: https://owlcation.com/stem/Naked-Mole-Rats-Strange-Discoveries-About-an-...

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Vierailija

Aika jännä tuo yksityiskohta mitä aiemmin olen kuullut että apoptoosin sijasta kaljurotilla on käytössä nekroosi(tuohon kait se hyaluronihapon muunnos viittaa?).

Kiinnostaisi kuulla  miten sitten se dna-vaurioiden korjaaminen? Onko niillä jotain korvaavaa juttua telomeraasille vai mitenkä?

Käyttäjä4499
Seuraa 
Viestejä4410
Liittynyt21.7.2017

ksuomala kirjoitti:
Aika jännä tuo yksityiskohta mitä aiemmin olen kuullut että apoptoosin sijasta kaljurotilla on käytössä nekroosi(tuohon kait se hyaluronihapon muunnos viittaa?).

Kiinnostaisi kuulla  miten sitten se dna-vaurioiden korjaaminen? Onko niillä jotain korvaavaa juttua telomeraasille vai mitenkä?

Hyviä kysymyksiä! En miettinyt tuota, kun en päässyt lukemaan HS:n juttua.

Tässä perusjuttua alkuun:

Telomerase activity coevolves with body mass, not lifespan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693359/

Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637185/

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Käyttäjä4499
Seuraa 
Viestejä4410
Liittynyt21.7.2017

Mielenkiintoista vertailua:

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511137/

(concerted necrotic cell death = CCD)

naked mole rat cells easily undergo apoptosis and do not favor necrosis in response to stress (14).

Blind mole rats Spalax  (BMR) cells proliferated actively for 7–20 population doublings, after which the cells began secreting IFN-β, and the cultures underwent massive necrotic cell death within 3 d. The necrotic cell death phenomenon was independent of culture conditions or telomere shortening. Interestingly, this cell behavior was distinct from that observed in another long-lived and cancer-resistant African mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity to contact inhibition. 

--When cells are cultured in vitro they are subjected to growth factors from FBS and are forced to proliferate because of frequent subculture at low cell density. These strong progrowth signals may be recognized by BMR cells as a potentially oncogenic signaling imbalance and trigger a cell death response. This mechanism resembles oncogene-induced senescence of human cells, where cells enter irreversible arrest in response to hyperproliferative signals, such as expression of activated oncogenes (16, 17). Another similarity with oncogene-induced senescence is that CCD of BMR cells is independent of telomere shortening and occurs in cells with long telomeres.

Despite necrosis being commonly viewed as less precise or as an inefficient way of eliminating unwanted cells, BMRs have evolved a highly efficient antitumor mechanism based on necrotic response. An advantage of necrosis could be in eliminating all cells surrounding the premalignant lesion, which may provide an added antitumor effect by eliminating reactive tumor stroma, including tumor-activated fibroblasts (18).

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Käyttäjä4499
Seuraa 
Viestejä4410
Liittynyt21.7.2017

Most intriguing, fibroblast cells only from Spalax, but not from other species, inhibit growth and kill cancer cells, but not normal cells, from various tissues and species, most importantly a wide range of human cancer cells. This is exhibited in both co-culture system or by exposure to factors secreted into conditioned media harvested from Spalax fibroblasts. Decreased cancer cell viability and proliferation, reduced colony formation in soft agar, disturbed cell cycle progression, chromatin condensation, nuclei deformation and mitochondrial fragmentation were reproducibly observe.

Molecular Biology studies of the Hypoxia- and Cancer- Tolerance of the Subterranean Mole Rat, Spalax

http://evolution.haifa.ac.il/index.php/29-people/personal-websites/77-pe...

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Vierailija

En nyt vielä saanut aikaiseksi kaikkia linkejä kahlata läpi. Jotain tuli selailtua kyllä.

Mutta siis:

nuo telomeerit ja telomeraasit kaljurotilla samanlaisia kuin muilla saman kokoluokan jyrsijöillä vaiko ei?

Telomeraasihan vaikutti vain telomeereihin, right? Miten sitten tuo dna-vaurioiden  korjaaminen muuten kuin telomeerien osalta, erilaista kuin muilla jyrsijöillä?

Ja tuo hyaluronihappo, erillinen CCD:stä?

Yhdessä vaiheessa harkitsin että noihin biologia-asioihin tutustuisi vähän lukiotasoa syvemmin.

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