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Liittynyt12.5.2014

The Role of Mercury in Cardiovascular Disease

Mark C. Houston1,2,3*

1Associate Clinical Professor of Medicine, Vanderbilt University School of Medicine, USA

2Director, Hypertension Institute and Vascular Biology, USA

3Medical Director, Division of Human Nutrition, Saint Thomas Medical Group, Saint Thomas Hospital, Nashville, Tennessee, USA

Abstract

Mercury toxicity is highly correlated with hypertension, coronary heart disease (CHD), myocardial infarction (MI),

stroke and other cardiovascular disease. Mercury has a high affinity for sulfhydryl (-SH) groups, which inactivates

numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants [NAC (n-acetyl cysteine, ALA

(alpha lipoic acid), GSH (glutathione)], with subsequent decreased oxidant defense and increased oxidative stress.

Mercury binds to metallothionein and substitutes for zinc, copper, and other trace metals reducing the effectiveness

of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in ATP, depletion of glutathione, and

increased lipid peroxidation. Selenium and fish containing omega 3 fatty acids or omega 3 fatty acids supplements

with DHA and EPA antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative

stress, inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction and hypertrophy,

endothelial dysfunction, dyslipidemia, immune and mitochondrial dysfunction. The clinical consequences of

mercury toxicity include hypertension, CHD, MI, cardiac arrhythmias, reduced heart rate variability, increased

carotid IMT and carotid artery obstruction, CVA, generalized atherosclerosis, renal dysfunction, renal insufficiency

and proteinuria. Pathological and biochemical findings correlate with the clinical manifestations of mercury toxicity.

Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates COMT (catecholamine

0 methyl transferase), which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect

will increase blood pressure and may be a clinical clue to mercury- induced heavy metal toxicity. Mercury toxicity

should be evaluated in any patient with hypertension, CHD, MI, CVD, CVA or other vascular disease. Specific testing

for acute and chronic toxicity and total body burden using hair, toenail, urine and serum should be done with both

baseline and provocation methods.

The Role of Mercury in Cardiovascular Disease

Mark C. Houston1,2,3*

1Associate Clinical Professor of Medicine, Vanderbilt University School of Medicine, USA

2Director, Hypertension Institute and Vascular Biology, USA

3Medical Director, Division of Human Nutrition, Saint Thomas Medical Group, Saint Thomas Hospital, Nashville, Tennessee, USA

Abstract

......Kymmeniä elohopeasta johtuvia haittoja, alkuperäisessä artikkelissa.

Selenium and fish containing omega 3 fatty acids or omega 3 fatty acids supplements

with DHA and EPA antagonize mercury toxicity.

.....

Elohopean vaaroista ei paljon puhuta, vaikka ne ovat huomattavat aiheuttaen esim. aivojen toiminnan häiriöitä sekä sydämen ja verisuoniston sairauksia.  Myös näiden sairauksien syvimmän syyn, kehoon varastoituneen elohopean poisto kelatoimalla jää sanomatta.  Kelaatiohoitoon työterveyslääkärinä toimiessaan tottunut tri Matti Tolonen puhuu elohopean vaaroista ja kertoo kelaatiohoidoista  monessa kirjoituksessaan "Tohtori Tolonen, elohopea".  Ilmenee, että yllä mainittujen omega 3:n ja seleenin lisäksi mm. C-vitamiini ja karnosiini ovat hyödyksi kelaatiohoidon ohella.

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